Development of Porous Photopolymer Resin-SWCNT Produced by Digital Light Processing Technology Using for Bone Femur Application

Document Type : RESEARCH PAPER

Authors

1 1 Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 2 Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran

2 Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran

3 Department of Orthopedic, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Rothman Institute, Thomas Jefferson University, Department of Orthopaedic Surgery, Philadelphia, PA, USA

5 Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

6 New Technologies Research Center, Amirkabir University of Technology, Tehran, Iran

Abstract

Background: Although bone tissue has the unique characteristic of self-repair in fractures, bone grafting is needed in some
situations. The synthetic substances that are used in such situations should bond to the porous bones, be biocompatible
and biodegradable, and do not stimulate the immune responses. Biomaterial engineering is the science of finding and
designing novel products. In principle, the most suitable biodegradable matrix should have adequate compressive strength
of more than two megapascals. At this degradation rate, the matrix can eventually be replaced by the newly formed bone,
and the osteoprogenitor cells migrate into the scaffold. This study aimed to evaluate the fabrication of a scaffold made of
polymer-ceramic nanomaterials with controlled porosity resembling that of spongy bone tissue.
Methods: A compound of resin polymer, single-walled carbon nanotube (SWCNT) as reinforcement, and hydroxyapatite
(HA) were dissolved using an ultrasonic and magnetic stirrer. A bio-nano-composite scaffold model was designed in the
SolidWorks software and built using the digital light processing (DLP) method. Polymer-HA scaffolds with the solvent system
were prepared with similar porosity to that of human bones.
Results: HA-polymer scaffolds had a random irregular microstructure with homogenizing porous architecture. The SWCNT
improved the mechanical properties of the sample from 25 MPa to 36 MPa besides having a proper porosity value near
55%, which can enhance the transformation and absorption of protein in human bone.
Conclusion: The combined bio-nanocomposite had a suitable porous structure with acceptable strength that allowed it to
be used as a bone substitute in orthopedic surgery.

Keywords

References

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The Archives of Bone and Joint Surgery
Volume 9, Issue 4
July and August 2021
Pages 445-452

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History

  • Receive Date: 22 December 2019
  • Revise Date: 11 August 2020
  • Accept Date: 26 September 2020

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