Dupuytren’s Disease: Predicting Factors and Associated Conditions. A Single Center Questionnaire-Based CaseControl Study

Document Type : RESEARCH PAPER

Authors

1 University of Milan, Residency Program in Orthopaedics and Trauma Surgery, Milan, Italy IRCCS Galeazzi Orthopaedic Institute, Milan, Italy

2 Orthopaedics and Traumatology Department, San Raffaele Scientific Institute, Milan, Italy

Abstract

Background: Conflicting studies link several conditions and risk factors to Dupuytren’s disease (DD). A questionnaire-based case-control study was set to investigate associated conditions and clinical features of DD in a sample of Italian patients. The main purpose was the identification of predicting factors for: DD development; involvement of multiple rays; involvement of both hands; development of radial DD; development of recurrences and extensions. Methods: A self-administered questionnaire was used to investigate medical and drug histories, working and life habits, DD clinical features, familial history, recurrences and extensions. Binary logistic regression, Mann Whitney U-test and Fisher’s exact test were used for the statistical analysis. Results: A role in DD development was found for male sex, cigarette smoking, diabetes and heavy manual work. The development of aggressive DD has been linked to age, male sex, high alcohol intake, dyslipidemias and positive familial history. Conclusion: Further studies might explain the dual relationship between ischemic heart disease and DD. According to our results, the questionnaire used for this study revealed to be an easy-handling instrument to analyze the conditions associated to DD. Nevertheless, its use in further and larger studies is needed to confirm our results as well as the role of the questionnaire itself as investigation tool for clinical studies.

Keywords

Main Subjects

References

1. Dolmans GH, Werker PM, Hennies HC, Furniss D, Festen
EA, Franke L, et al. Wnt signaling and Dupuytren’s
disease. N Engl J Med. 2011; 365(4):307-17.
2. Hu FZ, Nystrom A, Ahmed A, Palmquist M, Dopico R,
Mossberg I, et al. Mapping of an autosomal dominant
gene for Dupuytren’s contracture to chromosome 16q
in a Swedish family. Clin Genet. 2005; 68(5):424-9.
3. Carvalhana G, Auquit-Auckbur I, Milliez PY.
Dupuytren’s disease: state of knowledge and research
in physiopathology. Chir Main. 2011; 30(4):239-45.
4. Dolmans GH, de Bock GH, Werker PM. Dupuytren
diathesis and genetic risk. J Hand Surg Am. 2012;
37(10):2106-11.
5. Hindocha S, Stanley JK, Watson S, Bayat A. Dupuytren’s
diathesis revisited: evaluation of prognostic indicators
for risk of disease recurrence. J Hand Surg Am. 2006;
31(10):1626-34.
6. Gudmundsson KG, Arngrì􀆰msson R, Sigfùsson N,
Björnsson A, Jònsson T. Epidemiology of Dupuytren’s
disease: clinical, serological and social assessment.
The Reykjavik Study. J Clin Epidemiol. 2000;
53(3):291-6.
7. Godtfredsen NS, Lucht H, Prescott E, Sørensen TI,
Grønbaek M. A prospective study linked both alcohol
and tobacco to Dupuytren’s disease. J Clin Epidemiol.
2004; 57(8):858-63.
8. Noble J, Heathcote JG, Cohen H. Diabetes mellitus in
the aetiology of Dupuytren’s disease. J Bone Joint Surg
Br. 1984; 66(3):322-5.
9. Arafa M, Noble J, Royle SG, Trail IA, Allen J. Dupuytren’s
and epilepsy revisited. J Hand Surg Br. 1991;
17(2):221-4.
10. Elliot D, Ragoowansi R. Dupuytren’s disease
secondary to acute injury, infection or operation distal
to the elbow in the ipsilateral upper limb--a historical
review. J Hand Surg Br. 2005; 30(2):148-56.
11. Descatha A, Bodin J, Ha C, Goubault P, Lebreton M,
Chastang JF, et al. Heavy manual work, exposure
to vibration and Dupuytren’s disease? Results of a
surveillance program for musculoskeletal disorders.
Occup Environ Med. 2012; 69(4):296-9.
12. Bower M, Nelson M, Gazzard BG. Dupuytren’s
contractures in patients infected with HIV. BMJ. 1990;
300(6718):164-5.
13. Livingstone JA, Field J. Algodistrophy and its
association with Dupuytren’s disease. J Hand Surg Br.
1999; 24(2):199-202.
14. Arafa M, Steingold RF, Noble J. The incidence of
Dupuytren’s disease in patients with rheumatoid
arthritis. J Hand Surg Br. 1984; 9(2):165-6.
15. Mikkelsen OA, Høyeraal HM, Sandvik L. Increased
mortality in Dupuytren’s disease. J Hand Surg Br.
1999; 24(5):515-8.
16. Wilbrand S, Ekbom A, Gerdin B. Cancer incidence
in patients treated surgically for Dupuytren’s
contracture. J Hand Surg Br. 2000; 25(3):283-7.
17. Smith SP, Devaraj VS, Bunker TD. The association
between frozen shoulder and Dupuytren’s disease. J
Shoulder Elbow Surg. 2001; 10(2):149-51.
18. Armstrong JR, Hurren JS, Logan AM. Dermofasciectomy
in the management of Dupuytren’s disease. J Bone
Joint Surg. 2000; 82(1):90-4.
19. Eadington DW, Patrick AW, Frier BM. Association
between connective tissue changes and smoking
habit in type 2 diabetes and in non-diabetic humans.
Diabetes Res Clin Pract. 1991; 11(2):121-5.
20. Roy S, Trudeau K, Roy S, Behl Y, Dhar S, Chronopoulos
A. New insights into hyperglycemia-induced
molecular changes in microvascular cells. J Dent Res.
2010; 89(2):116-27.
21. Wiernsperger N, Rapin JR. Microvascular diseases: is
a new era coming? Cardiovasc Hematol Agents Med
Chem. 2012; 10(2):167-83.
22. Larkin ME, Barnie A, Braffett BH, Cleary PA, Diminick
L, Harth J, et al. Musculoskeletal complications in
Type 1 Diabetes. Diabetes Care. 2014; 37(7):1863-9.
23. Yeh CC, Huang KF, Ho CH, Chen KT, Liu C, Wang JJ, et al.
Epidemiological profile of Dupuytren’s disease in Taiwan
(Ethnic Chinese): a nationwide population-based study.
BMC Musculoskelet Disord. 2015; 16(1):20.
24. Lusis AJ. Atherosclerosis. Nature. 2000; 407(6801):
233-41.
25. Weber C, Noels H. Atherosclerosis: current
pathogenesis and therapeutic options. Nat Med. 2011;
17(11):1410-22.
26. Goldblum JR, Folpe AL, Weiss SW. Benign fibroblastic/
myofibroblastic proliferations, including superficial
fibromatoses. Enzinger and Weiss’s Soft Tissue
Tumors. 6th ed. Philadelphia: Elsevier Saunders; 2014.
P. 188-255.
27. Mayerl C, Del Frari B, Parson W, Boeck G, Piza-Katzer
H, Wick G, et al. Characterisation of the inflammatory
response in Dupuytren’s disease. J Plastic Surg Hand
Surg. 2016; 50(3):171-9.
28. Gudmundsson KG, Arngrì􀆰msson A, Sigfùsson N,
Jònsson T. Increased total mortality and cancer
mortality in men with Dupuytren’s disease: a 15-year
follow-up study. J Clin Epidemiol. 2002; 55(1):5-10.
29. Abe Y, Rokkaku T, Ofuchi S, Tokunaga S, Takahashi K,
Moriya H. Dupuytren’s disease on the radial aspect of
the hand: report on 135 hands in Japanese patients. J
Hand Surg Br. 2004; 29(4):359-62.
30. Bellosta S, Bernini F, Ferri N, Quarato P, Canavesi M,
Arnaboldi L, et al. Direct vascular effects of HMGCoA
reductase inhibitors. Atherosclerosis. 1998;
137(Suppl):S101-9.
The Archives of Bone and Joint Surgery
Volume 5, Issue 6
November 2017
Pages 384-393

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History

  • Receive Date: 31 December 2016
  • Revise Date: 25 January 2017
  • Accept Date: 15 April 2017

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