Influence of Sexuality in Functional Recovery after Spinal Cord Injury in rats

Document Type : RESEARCH PAPER


1 Department of Neurosurgery, Guilan University of Medical Sciences, Rasht, Iran

2 Department of P harmacology, Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran

3 Department of Physiology, Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran

4 Department of Neurosurgery, Ghaem Hospital, Mashhad, Iran


Background: Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injury in Wistar Rats.

Spinal cord lesions were made by compressing the cord at T9 level and making a spinal cord contusion. Routine care of each rat was done daily. The LSS scoring system was used to measure the locomotion of these rats and to compare the recovery rate between male and female rats.

The results suggested that there was no significant difference between the two sex in recovery.

To be female does not seem to be a prognostic factor for recovery after SCI. However, this preliminary study should be repeated in other animals and in larger cohorts.


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