Tissue Engineering Technologies in the Management of Bone Infections

Document Type : In Brief

Authors

1 Department of Orthopedic Surgery, Hospital Universitario La Paz, Madrid, Spain

2 Department of Orthopedic Surgery, Hospital Universitario de Jaén, Jaén, Spain

10.22038/abjs.2024.83537.3804

Abstract

Osteomyelitis is a calamitous illness produced by microbial infection in deep osseous tissue. Its elevated recurrence percentage is a major defiance in management. Besides, microbial-mediated dysregulation of the osseous tissue immune microhabitat hinders the process of osseous regeneration, resulting in defective repair of the osseous defect. In spite of advancements in surgical approaches and medication employments for the management of infections of the osseous tissue within the most recent years, dares endure in clinical treatment. The creation and employment of tissue engineering materials have rendered new approaches for the management of infections of the osseous tissue. In the discipline of tissue engineering, we should center on utilizing materials science and engineering technology to create biomimetic 3D printed degradable frameworks with structure, layout, and mechanical attributes; accomplishing controlled liberation of antimicrobial medications via nanocarriers or scaffold surface coating technologies; and utilizing coaxial printing or gradient printing techniques to accomplish graded controlled liberation of antimicrobial medications and osteogenic active drugs.
        Level of evidence: III

Keywords

Main Subjects


  1. Masters EA, Trombetta RP, de Mesy Bentley KL, et al. Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy". Bone Res. 2019; 7:20. doi: 10.1038/s41413-019-0061-z.
  2. Masters EA, Ricciardi BF, Bentley KL, Moriarty TF, Schwarz EM, Muthukrishnan G. Skeletal infections: microbial pathogenesis, immunity and clinical management. Nat Rev Microbiol. 2022; 20(7):385-400. doi: 10.1038/s41579-022-00686-0.
  3. Qin L, Yang S, Zhao C, et al. Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections. Bone Res. 2024; 12(1):28. doi: 10.1038/s41413-024-00332-w.
  4. Zhou Z, Feng W, Moghadas BK, et al. Review of recent advances in bone scaffold fabrication methods for tissue engineering for treating bone diseases and sport injuries. Tissue Cell. 2024; 88:102390. doi: 10.1016/j.tice.2024.102390.
  5. Zhou H, Zhu Y, Yang B, et al. Stimuli-responsive peptide hydrogels for biomedical applications. J Mater Chem B. 2024; 12(7):1748-1774. doi: 10.1039/d3tb02610h.
  6. Zegre M, Barros J, Ribeiro IAC, et al. Poly (DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms. Int J Pharm. 2022; 622:121832. doi: 10.1016/j.ijpharm.2022.121832.
  7. Xue X, Hu Y, Wang S, Chen X, Jiang Y, Su J. Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering. Bioact. Mater. 2022; 12:327-339. doi: 10.1016/j.bioactmat.2021.10.029.
  8. Zhan S, Guo AXY, Cao SC, Liu N. 3D printing soft matters and applications: a review. Int J Mol Sci. 2022; 23(7):3790. doi: 10.3390/ijms23073790.
  9. Grenier J, Duval H, Lv P, et al. Interplay between crosslinking and ice nucleation controls the porous structure of freeze-dried hydrogel scaffolds. Biomater Adv. 2022; 139:212973. doi: 10.1016/j.bioadv.2022.212973.
  10. Zhang X, He J, Qiao L, et al. 3D printed PCLA scaffold with nano-hydroxyapatite coating doped green tea EGCG promotes bone growth and inhibits multidrug-resistant bacteria colonization. Cell Prolif. 2022; 55(10):e13289. doi: 10.1111/cpr.13289.
  11. Xulin H, Hu L, Liang Q, et al. 369 fabrication of 3D gel-printed β-tricalcium phosphate/titanium dioxide porous scaffolds for cancellous bone tissue engineering. Int J Bioprint. 2023; 9(2):673. doi: 10.18063/ijb.v9i2.673.
  12. Mirasadi K, Rahmatabadi D, Ghasemi I, et al. 3D and 4D printing of PETG-ABS-Fe(3)O(4) nanocomposites with supreme remotely driven magneto-thermal shape-memory performance. Polymers (Basel). 2024; 16(10):1398. doi: 10.3390/polym16101398.
  13. Rosenquist J, Folkesson M, Höglund L, Pupkaite J, Hilborn J, Samanta A. An injectable, shape-retaining collagen hydrogel crosslinked using thiol-maleimide click chemistry for sealing corneal perforations. ACS Appl Mater Interfaces.2023; 15(29):34407-34418. doi: 10.1021/acsami.3c03963.
  14. Guo Y, Wang M, Liu Q, Liu G, Wang S, Li J. Recent advances in the medical applications of hemostatic materials. Theranostics. 2023; 13(1):161-196. doi: 10.7150/thno.79639.
  15. Li Y, Liu Z, Zhao C, et al. A sustained-release PDGF-BB nanocomposite hydrogel for DM associated bone regeneration. J Mater Chem B. 2023; 11(5):974-984. doi: 10.1039/d2tb02037h.
  16. Wassif RK, Elkheshen SA, Shamma RN, Amer MS, Elhelw R, El-Kayal M. Injectable systems of chitosan in situ forming composite gel incorporating linezolid-loaded biodegradable nanoparticles for long-term treatment of bone infections. Drug Deliv Transl Res. 2024; 14(1):80-102. doi: 10.1007/s13346-023-01384-x.
  17. Liu X, Gaihre B, Park S, et al. 3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration. Bioact Mater. 2023; 27:216-230. doi: 10.1016/j.bioactmat.2023.03.021.
  18. Liu D, Liu J, Zhao P, et al. 3D bioprinted tissue-engineered bone with enhanced mechanical strength and bioactivities: accelerating bone defect repair through sequential immunomodulatory properties. Adv Healthc Mater. 2024:e2401919. doi: 10.1002/adhm.202401919.
  19. Ghasemi F, Jahani A, Moradi A, Ebrahimzadeh MH, Jirofti N. Different modification methods of poly methyl methacrylate (PMMA) bone cement for Orthopedic Surgery applications. Arch Bone Jt Surg. 2023; 11(8):485-492. doi: 10.22038/ABJS.2023.71289.3330.
  20. Ghassemi T, Ghoddusi J, Moradi A. Teaming up; a critical "must do" for clinically bone tissue engineering. Arch Bone Jt Surg. 2023; 11(6):376-377. doi: 10.22038/ABJS.2023.69762.3297.