Helical, Spring and Curled Nano/Micro Fibrous Structures for Tissue Engineering Application

Document Type : CURRENT CONCEPTS REVIEW

Authors

1 Orthopedic Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Science, Mashhad, Iran - Bone and Joint Research laboratory, Ghaem Hospital, Mashhad University of Medical Science, Mashhad, Iran

2 Orthopedic Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Science, Mashhad, Iran - Bone and Joint Research laboratory, Ghaem Hospital, Mashhad University of Medical Science, Mashhad, Iran - Faculty of New Sciences and Technologies, Department of biomedical engineering, Semnan University, Semnan, Iran

3 Chemical Engineering Department, University of Sistan and Baluchestan, Zahedan, Iran - Institute of nanotechnology, University of Sistan and Baluchestan, Zahedan, Iran

10.22038/abjs.2025.80254.3663

Abstract

Over the past few decades, the engineering of helical, spring, curled, and hierarchically structured 
nano/microfibers has attracted considerable attention due to their unique characteristics and potential 
applications in tissue engineering and various industrial fields. Understandin g the parameters and 
processes involved in the fabrication of these fibers is essential. This comprehensive review outlines 
recent advancements in research on helical nano/microfibers, focusing on processing techniques, fiber 
structure, and property characterization, and their applications in fields such as tissue engineering and 
regenerative medicine. The study also investigates the mechanical and hydrodynamic parameters that 
influence the fabrication of helical fibers using contemporary techniques. It hig hlights that helical 
structures form when electric and elastic forces are balanced due to non -uniform electric fields. The 
coaxial electrospinning technique, along with the use of polymers with varying elastic and conductive 
properties, plays a crucial role in producing these structures. The distinctive properties of helical 
nanofibers, such as their mechanical strength, high porosity, biocompatibility, and ability to promote 
cellular activities, make them promising candidates for developing scaffolds in bo ne tissue engineering.
 Level of evidence: III

Keywords

Main Subjects

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The Archives of Bone and Joint Surgery
Volume 13, Issue 6
June 2025
Pages 323-336

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History

  • Receive Date: 31 May 2024
  • Revise Date: 09 January 2025
  • Accept Date: 09 January 2025

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