The Efficacy and Safety of Orthobiologic Treatments for Greater Trochanteric Pain Syndrome: A Comprehensive Scoping Review

Document Type : SCOPING REVIEW

Authors

1 1 Andrews Institute for Orthopedics and Sports Medicine, Gulf Breeze, FL, USA 2 Orthopedic Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Radiology, Shiraz University of Medical Sciences, Zand Street, Shiraz, Iran

3 Andrews Institute for Orthopedics and Sports Medicine, Gulf Breeze, FL, USA

4 Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

5 Department of Orthopedic Surgery, School of medicine, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

6 Orthopedic Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran

7 Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

10.22038/abjs.2024.82620.3762

Abstract

Objectives: This scoping review aims to evaluate the safety and efficacy of orthobiologics in the 
treatment of Greater Trochanteric Pain Syndrome (GTPS), with a focus on pain relief, functional 
improvement, and quality of life.
Methods: We conducted a comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, Scopus, 
Google Scholar, and CINAHL for studies published from January 1, 2000, to March 20, 2024. Eligible studies 
included case series, cohort studies, case-control studies, and randomized controlled trials (RCTs) that investigated 
the use of orthobiologics for GTPS. The primary outcomes assessed were pain, function, and quality of life. The 
quality of the studies was evaluated using the JADAD scale, the Cochrane Risk of Bias Tool, and the MINORS 
score.
Results: The review included 19 studies involving a total of 811 participants. Platelet-rich plasma (PRP) was found 
to significantly reduce pain, as measured by the VAS scores, and to improve functional outcomes including the 
modified Harris Hip Score (mHHS) and the Western Ontario and McMaster Universities Osteoarthritis Index 
(WOMAC) scores. These findings suggest that PRP may be an effective treatment for GTPS. The studies reported 
minimal side effects that were generally mild and transient.
Conclusion: PRP and other orthobiologic treatments show promise in managing GTPS, showing good safety 
profiles and potential benefits. However, further high-quality RCTs are necessary to confirm long-term efficacy and 
to establish standardized treatment protocols.
 Level of evidence: II

Keywords

Main Subjects


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