A Midterm Analysis of Outcomes of Septic Arthritis of Hip Treated With Two Stage Cement Spacer and Total Hip Arthroplasty

Document Type : RESEARCH PAPER

Authors

1 Fortis Hospital, Mohali, Punjab, India

2 Max Superspecialty Hospital, Mohali, Punjab, India

Abstract

Objectives: Septic arthritis of the hip, if not managed early and adequately, leads to degenerative 
arthritis with pain and debility. Various treatment options have been recommended, but no guidelines 
for the same have been established. Aim of the study is to evaluate the efficacy of our protocol for 
timing of staging using serological markers, rate of periprosthetic joint infection, midterm implant 
survivorship and functional outcomes.
Methods: Thirteen patients, aged 25 years and above, suffering from degenerative hip arthritis secondary to septic 
hip, were treated with 2 stage total hip replacement according to our protocol and serological markers were assessed 
for the timing of stages and follow up of infection control. Outcome of success of two stage total hip arthroplasty was 
assessed using modified Delphi criteria.
Results: Both acetabulum and femur head were involved in all cases. Two patients had history of a previous hip 
surgery. Most common micro-organism detected in intraoperative cultures was Staphylococcus aureus. Mean Harris 
Hip Score at final follow up was 82.33. Final outcome was deemed to be excellent in 84.6 % and good in 15.4 % 
cases.
Conclusion: Septic arthritis of the hip leading to end stage degenerative joint disease can be effectively managed 
with two stage total hip arthroplasty with good to excellent clinical and functional results.
 Level of evidence: IV

Keywords

Main Subjects


1. Matthews PC, Dean BJ, Medagoda K, et al. Native hip joint 
septic arthritis in 20 adults: delayed presentation beyond 
three weeks predicts need for excision arthroplasty. J Infect. 
2008; 57(3):185-190. doi:10.1016/j.jinf.2008.07.001.
2. Mathews CJ, Weston VC, Jones A, Field M, Coakley G. Bacterial 
septic arthritis in adults. Lancet. 2010; 375(9717):846-855. 
doi:10.1016/S0140-6736(09)61595-6.
3. Charlton WP, Hozack WJ, Teloken MA, Rao R, Bissett GA. 
Complications associated with reimplantation after 
girdlestone arthroplasty. Clin Orthop Relat Res. 2003 
;(407):119-126. doi:10.1097/00003086-200302000-00019.
4. Chen CE, Wang JW, Juhn RJ. Total hip arthroplasty for primary 
septic arthritis of the hip in adults. Int Orthop. 2008; 
32(5):573-580. doi:10.1007/s00264-007-0366-1.
5. Anagnostakos K, Duchow L, Koch K. Two-stage protocol and 
spacer implantation in the treatment of destructive septic 
arthritis of the hip joint. Arch Orthop Trauma Surg. 2016; 
136(7):899-906. doi:10.1007/s00402-016-2455-3.
6. Fleck EE, Spangehl MJ, Rapuri VR, Beauchamp CP. An 
articulating antibiotic spacer controls infection and improves 
pain and function in a degenerative septic hip. Clin Orthop 
Relat Res. 2011; 469(11):3055-3064. doi:10.1007/s11999-
011-1903-1.
7. Carpenter CR, Schuur JD, Everett WW, Pines JM. Evidencebased diagnostics: adult septic arthritis. Acad Emerg Med. 
2011; 18(8):781-796. doi:10.1111/j.1553-
2712.2011.01121.x.
8. Harris WH. Traumatic arthritis of the hip after dislocation and 
acetabular fractures: treatment by mold arthroplasty. An endresult study using a new method of result evaluation. J Bone 
Joint Surg Am. 1969; 51(4):737-755.
9. Diaz-Ledezma C, Higuera CA, Parvizi J. Success after
treatment of periprosthetic joint infection: a Delphi-based 
international multidisciplinary consensus. Clin Orthop Relat 
Res. 2013; 471(7):2374-2382. doi:10.1007/s11999-013-
2866-1.
10. Grauer JD, Amstutz HC, O'Carroll PF, Dorey FJ. Resection 
arthroplasty of the hip. J Bone Joint Surg Am. 1989; 
71(5):669-678.
11. Marchetti PG, Toni A, Baldini N, et al. Clinical evaluation of 
104 hip resection arthroplasties after removal of a total hip 
prosthesis. J Arthroplasty. 1987; 2(1):37-41. 
doi:10.1016/s0883-5403(87)80029-3.
12. Seo JG, Moon YW, Park SH, Han KY, Kim SM. Primary total knee arthroplasty in infection sequelae about the native knee. 
J Arthroplasty. 2014; 29(12):2271-2275. 
doi:10.1016/j.arth.2014.01.013.
13. El-Ganzoury I, Eid AS. Two-stage arthroplasty using 
functional temporary prosthesis to treat infected arthroplasty 
and septic arthritis of the hip. J Orthop. 2014; 12(Suppl 
1):S86-S93. doi:10.1016/j.jor.2014.04.006.
14. D'Angelo F, Monestier L, Zagra L. Active septic arthritis of the 
hip in adults: what's new in the treatment? A systematic 
review. EFORT Open Rev. 2021; 6(3):164-172. 
doi:10.1302/2058-5241.6.200082.
15. Huang TW, Huang KC, Lee PC, Tai CL, Hsieh PH. Encouraging 
outcomes of staged, uncemented arthroplasty with shortterm antibiotic therapy for treatment of recalcitrant septic 
arthritis of the native hip. J Trauma. 2010; 68(4):965-969. 
doi:10.1097/TA.0b013e3181af6e70.
16. Russo A, Cavagnaro L, Chiarlone F, Clemente A, Romagnoli S, 
Burastero G. Clinical outcomes and survivorship of two-stage 
total hip or knee arthroplasty in septic arthritis: a 
retrospective analysis with a minimum five-year follow-up. 
Int Orthop. 2021; 45(7):1683-1691. doi:10.1007/s00264-
021-05013-5.
17. Barton CB, Wang DL, An Q, Brown TS, Callaghan JJ, Otero JE. 
Two-Stage Exchange Arthroplasty for Periprosthetic Joint 
Infection Following Total Hip or Knee Arthroplasty Is 
Associated With High Attrition Rate and Mortality. J 
Arthroplasty. 2020; 35(5):1384-1389. 
doi:10.1016/j.arth.2019.12.005.
18. Burastero G, Alessio-Mazzola M, Cavagnaro L, et al. 
Conservative two-stage revision with primary components of 
infected total hip arthroplasty: An analysis of survival, clinical 
and radiographic outcomes. PLoS One. 2020; 
15(10):e0239981. Published 2020 Oct 1. 
doi:10.1371/journal.pone.0239981.
19. Alessio-Mazzola M, Repetto I, Russo A, et al. Permanent 
Spacers Are a Reliable Solution for Peri-prosthetic Shoulder 
Infection: A Systematic Review. HSS J. 2020; 16(3):272-279. 
doi:10.1007/s11420-020-09755-7.
20. Guntin J., Serino J., Rossi D., Boniello A., Gusho C., Della Valle C. 
Hypoalbuminemia Increases Mortality after Two-Stage 
Revision Total Joint Arthroplasty. Arch Bone Jt Surg. 2023; 
11(3): 173-179. doi: 10.22038/abjs.2022.65148.3123.
21. Shahi A., Parvizi J. Prevention of Periprosthetic Joint Infection. 
Arch Bone Jt Surg.2015; 3(2): 72-81. doi: 
10.22038/abjs.2015.3938.