Document Type : RESEARCH PAPER
Authors
1
University of Health Sciences, Faculty of Gulhane Medicine, Department of Orthopedics and Traumatology, Ankara, Türkiye
2
University of Health Sciences, Gulhane Faculty of Dentistry, Department of Basic Medical Sciences, Ankara, Türkiye
3
University of Health Sciences, Gülhane Vocational School of Health, Department of Pathology Ankara, Türkiye
4
Ankara Etlik City Hospital, Department of Family Medicine, Ankara, Türkiye
5
University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Biochemistry, Ankara, Türkiye
10.22038/abjs.2024.78412.3612
Abstract
Objectives: In this study, the Kellgren and Lawrence system was used as the most common radiographic
grading system for diagnosis of osteoarthritis in patients defined as Grade III and IV. It is aimed to
reveal oxidative stress and cellular immunity status. In this context, the aim is t o discuss possible risk
parameters regarding disease process and treatment effectiveness.
Methods: Twenty-five patients and 25 healthy individuals were included in the study. Total antioxidant, total
oxidative stress, and thiol-disulfide balance values were determined spectrophotometrically in blood samples taken
from individuals in the study groups. Neopterin levels were determined by the HPLC method.
Results: In our study, total antioxidant status (TAS) values were found to be lower in the healthy control group than
in the patient group (p=0.000). There was no statistically significant difference between the groups in total oxidant
status (TOS) (p=0.815). The oxidative stress index (OSI) value evaluated based on TAS and TOS values did not
show a statistical difference between the groups (p=0.065). The native thiol levels were determined to be statistically
significantly lower in the patient group (p=0.000). But, disulfide and neopterin values were statistically significantly
higher in the patient group (p=0.001 and p=0.000).
Conclusion: According to the findings of the current study; It is observed that the oxidant balance of individuals
with osteoarthritis is disrupted in favor of free radicals, and as a result, cellular immunity decreases due to
inflammation and the disease process. It is observed that these parameters change in direct proportion to the staging
of the disease, especially in patients with stage III-IV knee osteoarthritis.
Level of evidence: III
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