Multicentric Myxoid Liposarcoma; a Case Report and Literature Review

Document Type : CASE REPORT


1 Orthopedic Research Center, Imam Reza Hospital Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Pathology, Imam Reza Hospital Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Oncology, Imam Reza Hospital Mashhad University of Medical Sciences, Mashhad, Iran


Liposarcoma is a common malignant soft tissue tumor, accounting for 10% to 16% of all sarcomas. Multicentric myxoid liposarcoma is an uncommon condition. Differentiation between several primary tumors and metastasis of a single liposarcoma represents the main difficulty in diagnosis. A 47-years old woman presented with right thigh myxoid liposarcoma and underwent wide margin tumor resection. Other investigations like CXR, abdominal and pelvic CT-scans were negative. After 18 months another myxoid liposarma was found in her ipsi-lateral breast without any evidence of other organs metastasis.
Second lesion location, time between two presentation and cytogenetic differences are accepted criteria to site a sarcoma in multicentric category, but in myxoid liposarcoma these can be explained by the special features inherent to this tumor.


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