Effect of Dexmedetomidine on Postoperative Pain in Knee Arthroscopic Surgery; a Randomized Controlled Clinical Trial

Document Type : RESEARCH PAPER


1 Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Departmant of Orthopedic Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Mashhad University of Medical Sciences Mashhad Iran


knee surgery. The purpose of this study was to assess the analgesic effects of intra-articular injection of a dexmedetomidine
following knee arthroscopy.
Forty six patients schadualed for arthroscopic knee surgery under general anaesthesia, were randomly
devided into two groups. Intervention group received 1μg/kg dexmedetomidine (D) and isotonic saline. Control group
received 25ml isotonic saline (P). Analgesic effects were evaluated by measuring pain intensity (VAS scores) and
duration of analgesia.
There was no significant difference between the two groups in terms of age, sex and weight. The mean of
post-operation pain severity in 1, 3, 6,12, and 24 h was significantly lower in the intervention group (D) in comparison
with the control group (P). the mean of the total dose of tramadol consumption was significantly lower in the interven
group in comparison with the control group (
Intra-articular injection of dexmedetomidine at the end of arthroscopic knee surgery, alleviates the
patients’ pain; reducing the postoperative need for narcotics as analgesics, and increase the first analgesic request
after operation.


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