A Comparison between Pre-Incisional and Intraoperative Lidocaine Infiltration on Post-Incisional Surgical Pain in Microdiscectomy Surgery: A Randomized Clinical Trial Study

Document Type : RESEARCH PAPER


1 Department of Neurosurgery, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

2 2 Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 3 Clinical Research Development Unit, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Operating Room, School of Nursing, North Khorasan University of Medical Sciences, Bojnurd, Iran

4 Department of Neurosurgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

5 Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

6 Department of Nursing, School of Nursing, North Khorasan University of Medical Sciences, Bojnurd, Iran


Objectives: Effective postoperative pain control in microdiscectomy surgery is crucial to managing the 
disease and improving the patient's quality of life. Therefore, this study aimed to assess the potential 
effectiveness of 2% lidocaine in reducing pain immediately after discectomy surgery.
Methods: A total of 60 patients who underwent microdiscectomy surgery were enrolled in this randomized clinical 
trial study. They were randomly assigned to three groups: one group received lidocaine just before the incision, 
another group received lidocaine just before closing the incision, and the third group served as the control. Pain 
scores were measured at 1, 2, 3, 4, 8, and 12 h after the surgery using a Visual Analogue Scale.
Results: The demographic and clinical characteristics of the study population, including age, weight, length of 
surgery, gender, and history of diabetes, hypertension, and previous surgery, were comparable across all three 
groups (P>0.05). There was a significant reduction in pain scores over time in the groups that received lidocaine 
before (P<0.001) and during surgery (P=0.002). Moreover, there were significant differences in pain scores at all 
time points among the three groups. Both groups receiving lidocaine showed significantly lower pain scores than 
the control group (Pbefore surgery=0.005 and Pduring surgery<0.001). However, no significant difference was 
observed between the groups receiving lidocaine (P=0.080).
Conclusion: These findings highlight the effectiveness of a local injection of 2% lidocaine either before or during 
the surgery in managing post-incisional surgical pain after discectomy.
 Level of evidence: II


Main Subjects

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