Limb Saving with a Combination of Allogenic Platelets Rich Plasma, Fibrin Glue, and Collagen Matrix in an Open Fracture of the Tibia: A Case Report

Document Type : CASE REPORT


1 Department of Medical Genetics and Molecular Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


Tibia open fractures and lower limb soft tissue injuries are undesired conditions for orthopedic and 
general surgeons, and there is no ideal procedure for treating recalcitrant ulcers or severe traumatic 
ulcers. Recently, several novel approaches have been proposed, such as bone marrow stem cells, 
platelets, fibrin glue, and collagen matrix. The current study was conducted to evaluate the 
effectiveness of combining platelets, fibrin glue, and a collagen matrix for treating a serious limb -
threatening wound in a 33-year-old male with a right lower limb injury. After treatment, the wound was 
fully closed, tissue granulation was grown, skin grafting was done, and the right leg was saved. In 
conclusion, the combination of the mentioned components can be utilized to synergistically enhance 
wound healing and preserve the limb.
 Level of evidence: V


Main Subjects

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