Autologous and Allogenic Utilization of Stromal Vascular Fraction and Decellularized Extracellular Matrices in Orthopedic Surgery: A Scoping Review

Document Type : SCOPING REVIEW


Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain


This narrative review of the literature aims to analyze the use of stromal vascular fraction (SVF) and decellularized extracellular matrices (dECMs) in various pathologies related to orthopedic surgery. The reported results have shown that intra-articular injection of SVF seems to be a safe and effective technique for managing knee osteoarthritis. Platelet-rich plasma (PRP) and SVF are safe and effective management for recalcitrant Achilles tendinopathy in humans, although individuals managed with SVF recover earlier. There are promising results on utilizing adipose-derived mesenchymal stromal cells in chronic lateral elbow tendinopathy in athletes. Ready-to-use ECM/SVF gel appears to be a good therapeutic alternative promoting articular cartilage regeneration in patients with chondral injuries. SVF can safely be used to treat patients with chronic diabetic foot ulcers. There are insufficient high-quality data for utilizing cell-based treatment in sports injuries of the knee's soft tissues. Experimental studies suggest that SVF could be a new alternative to bone regeneration. Other experimental studies support the utilization of dECMs as a scaffold for the regeneration of large osseous defects, cell-derived dECMs scaffolds to repair articular cartilage injuries, and utilization of xenogeneic acellular muscles to manage volumetric muscle loss where there is a lack of donor site.
Level of evidence: III


Articles in Press, Accepted Manuscript
Available Online from 05 April 2022
  • Receive Date: 11 August 2021
  • Revise Date: 01 March 2022
  • Accept Date: 05 March 2022
  • First Publish Date: 05 April 2022