Orthobiologics: Current role in Orthopedic Surgery and Traumatology



Department of Orthopedic Surgery, La Paz University Hospital, Madrid, Spain


Orthobiologics are organic and synthetic materials that help in the cure of musculo-skeletal problems and are utilized
in Orthopaedic Surgery, both in and out of the surgical theater, to augment the possibilities of curing bone and soft
tissue lesions. Taking into account that their effect is frequently multifactorial and, in some occasions not entirely comprehended,
together with the insufficient clinical information, orthobiologics should be scrupulously assessed against
other secure and clinically accepted options. The fundamental orthobiologics today ready for use in Orthopedic Surgery
are the following: osseous hollow fillers, extracellular matrix (ECM) substances, platelet-rich plasma (PRP), bone
morphogenetic protein-2 (BMP-2), bone marrow aspirate (BMA), bone marrow aspirate concentrate (BMAC), and mesenchymal
stem cells (MSCs). It is predictable that in the time to come we will have more secure and more efficacious
orthobiologics. Meanwhile, it is paramount that orthopedic surgeons have appropriate information of contemporary
orthobiologics (biological adjuvants) so that they can utilize them correctly.
Level of evidence: III


Main Subjects

  • Receive Date: 15 October 2020
  • Revise Date: 02 July 2022
  • Accept Date: 30 January 2021
  • First Publish Date: 25 November 2021