Document Type : RESEARCH PAPER
Department of Orthopaedic and Trauma Surgery, University of Pisa, Italy
Department of Ophtalmology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
Department of Oncology and Surgery at Robotic Address of the Hospital Careggi University of Florence, Firenze FI, Italy
Department of Orthopaedic and Trauma Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Background: Megaprostheses are one of the preferred choices of reconstruction after tumor resection. Periprosthetic
joint infections are one of the most serious complications of joint prostheses surgeries. In this study, our aim was to
analyze the efficacy of silver-coated megaprostheses in reducing the risk of prosthesis-related infection.
Methods: One hundred forty-two patients who had undergone implantation of a mega-endoprosthesis for nonneoplastic or post-neoplastic conditions were included in this retrospective study. The end-point of the survival analysis
was the prosthesis failure due to infection.
Results: Thirty-eight patients had undergone implantation of a silver-coated megaprosthesis and 104 patients a
megaprosthesis without silver coating. The survival analysis showed an overall infection-free survival rate of 82.3% at
five years and 61.9% at 10 years. Silver-coated prostheses had an HR of 0.72 (95% CI: 0.26-2.05; P=0.54).
Conclusion: Implantation of a silver-coated mega-prosthesis in non-oncological patients did not significantly reduce
the risk of prosthesis-related infection.
Level of evidence: III