The Archives of Bone and Joint Surgery

The Archives of Bone and Joint Surgery

Effects of Vitamin D3 Fortified Low-fat Dairy Products on Bone Density Measures in Adults with Abdominal Obesity: A Randomized Clinical Trial

Document Type : RESEARCH PAPER

Authors
Payam Sharifan 1
Elahe Hassanzadeh 2
Maryam Mohammadi-Bajgiran 2
Vahid Reza Dabbagh 3
Elham Aminifar 4
Hamideh Ghazizadeh 5
Sara Saffar-Soflaei 5
Susan Darroudi 6
Davoud Tanbakouchi 7
Mohammad Reza Fazl-Mashhadi 8
Ali Ebrahimi-Dabagh 8
Mohammad Amin Mohammadi 8
Anahid Hemmatpur 9
Gordon A. Ferns 10
Habibollah Esmaily 7
Ramin Sadeghi 3
Majid Ghayour-Mobarhan 2
1 1.International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran 2 Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 3 Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
3 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4 Student Research Committee, Islamic azad University, Mashhad Branch, Mashhad, Iran
5 International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran- Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6 International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran - Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7 Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
8 Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
9 Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical sciences and health Services, Yazd, Iran
10 Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex, UK
10.22038/abjs.2021.57547.2850
Abstract
Background: Bone disease-related fractures constitute a heavy burden on the healthcare systems and economy.
Vitamin D is an important regulator of bone health and its deficiency is a global problem. This study aimed to evaluate
the effect of the 1,500 IU nano-encapsulated vitamin D used for fortifying low-fat dairy products (milk and yogurt) on
bone health parameters.
Methods: This parallel totally blinded, randomized controlled trial was part of the Ultraviolet Intake by Nutritional
Approach study and conducted on 306 individuals with abdominal obesity. Individuals were randomly assigned to
four groups, including fortified low-fat milk (1,500 IU nano-encapsulated vitamin D3 per 200 g/d), non-fortified low-fat
milk, fortified low-fat yogurt (1,500 IU nano-encapsulated vitamin D3 per 150 g/d), and non-fortified low-fat yogurt,
for 10 weeks between January and March 2019. Bone mineral density (BMD) and trabecular bone score (TBS) were
measured at the baseline and end of the trial. Trabecular bone score and BMD were defined as primary and secondary
outcomes.
Results: There were no significant differences in TBS and BMD between the intervention and control groups at the
end of the trial (P>0.05).
Conclusion: This trial demonstrated no significant effect of nano-encapsulated vitamin D fortified milk and yogurt on
BMD and TBS. There remains a need for longer-term trials regarding bone health outcomes to establish optimal doses
of fortification.
Level of evidence: I
Keywords
BMD
Bone health
Fortification
TBS
Vitamin D3
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The Archives of Bone and Joint Surgery
Volume 10, Issue 7
July 2022
Pages 601-610

  • Receive Date 26 June 2021
  • Revise Date 21 September 2021
  • Accept Date 18 October 2021