The Perioperative Management of Antiplatelet and Anticoagulant Drugs in Hip Fractures: Do the Surgery as Early as Possible



1 Joint Reconstruction Research Center, Tehran University of Medical Science, Tehran, Iran

2 1 Joint Reconstruction Research Center, Tehran University of Medical Science, Tehran, Iran 2 School of Medicine, Tehran University of Medical Science, Tehran, Iran


Hip fractures are among the most common fractures operated by orthopedic surgeons. Many elderly patients, who 
account for a significant percentage of hip fractures, suffer from medical conditions requiring antiplatelet and anticoagulant 
administration. Meanwhile, considerable evidence recommends early surgery within 48b hours of admission. We aim 
to review the existing evidence regarding the perioperative management of antiplatelet and anticoagulant drugs in hip 
fractures. It was concluded that surgery for hip fractures in patients with antiplatelet drug consumption should not be 
delayed unless a clear contraindication exists. Active reversal strategies are indicated for patients with hip fractures and 
warfarin therapy. However, evidence for the safety of these agents in pregnancy, breastfeeding state, and adolescence 
has not yet been established. Little data exists about perioperative management of direct-acting oral anticoagulants in 
hip fractures. Early surgery after 12-24 hours of drug cessation has been suggested in studies; however, it should be 
employed cautiously. Despite extensive research, the importance of the issue necessitates additional higher-quality 
Level of evidence: V


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