Foot Metastasis: Review of 38 Cases



1 Department of Orthopedic Surgery, Iran University of Medical Sciences, Tehran, Iran

2 Department of Orthopedic Surgery, Boston’s Children Hospital, Harvard Medical School, Boston, USA

3 Department of Orthopaedic Surgery, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


Background: Acrometastases are rare and account for approximately 0.1% of metastases. The most common primary
cancer site is the lung, followed by colorectal and genitourinary system.
Methods: We searched PubMed (www., Google scholar (, Science Direct (http://, and Springer ( databases, using a combination of controlled vocabulary
and text word terms and reviewed the last 10 years literature in order to describe demographic trends, anatomical
distribution, the most common primary sources of malignancy, and survival rates in the reports of foot metastases.
Results: In conclusion 38 cases were included in this review analysis. Lung and genitourinary system were the most
frequent primary sites.
Conclusion: Forefoot was involved in 71% of all metastases to foot either alone or in combination with other areas of
the foot. Calcaneus was involved in about 23% of patients either alone or in combination with other foot bones.
Level of evidence: IV


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