The Expanding Role of Biomarkers in Diagnosing Infection in Total Joint Arthroplasty: A Review of Current Literature



Department of Orthopaedics, Marshall University – Joan C. Edwards School of Medicine, Huntington, WV, USA


Consistent diagnosis of periprosthetic infection in total joint arthroplasty continues to elude the orthopedic surgeon
because no gold standard test exists. Therefore clinicians must rely on a combination of tests to help aid the diagnosis.
The expanding role of biomarkers has shown promising results to more accurately diagnose an infection when combined
with clinical suspicion and bacterial culture testing. This paper reviews the diagnostic capabilities of the most current
serum and synovial biomarkers as well as next generation sequencing in the setting of periprosthetic joint infection.
Future research and high-powered studies will be necessary to determine sensitivity and specificity of each biomarker.
Level of evidence: III


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