1. Srivastava A, Brewer AK, Mauser-Bunschoten EP,
Key NS, Kitchen S, Llinas A, et al. Guidelines for the
management of hemophilia. Haemophilia : the official
journal of the World Federation of Hemophilia.
2013;19(1):e1-47. PubMed PMID: 22776238. Epub
2012/07/11. eng.
2. Mortazavi SM, Haghpanah B, Ebrahiminasab MM,
Baghdadi T, Toogeh G. Functional outcome of total
knee arthroplasty in patients with haemophilia.
Haemophilia: the official journal of the World
Federation of Hemophilia. 2016;22(6):919-24. PubMed
PMID: 27561958. Epub 2016/08/27. eng.
3. Beeton K, Rodriguez-Merchan EC, Alltree J. Total
joint arthroplasty in haemophilia. Haemophilia : the
official journal of the World Federation of Hemophilia.
2000;6(5):474-81. PubMed PMID: 11012688. Epub
2000/09/30. eng.
4. Rodriguez-Merchan EC. Total joint arthroplasty: the
final solution for knee and hip when synovitis could
not be controlled. Haemophilia : the official journal
of the World Federation of Hemophilia. 2007;13
Suppl 3:49-58. PubMed PMID: 17822522. Epub
2007/10/18. eng.
5. Solimeno L, Luck J, Fondanesche C, McLaughlin P,
Narayan P, Sabbour A, et al. Knee arthropathy: when
things go wrong. Haemophilia : the official journal
of the World Federation of Hemophilia. 2012;18
Suppl 4:105-11. PubMed PMID: 22726092. Epub
2012/08/23. eng.
6. Rodriguez-Merchan EC, Heim M. Hemophilia
orthopedic management with emphasis on developing
countries. Seminars in thrombosis and hemostasis.
2005;31(5):518-26. PubMed PMID: 16276460. Epub
2005/11/09. eng.
7. Rodriguez-Merchan EC. Aspects of current
management: orthopaedic surgery in haemophilia.
Haemophilia : the official journal of the World
Federation of Hemophilia. 2012;18(1):8-16. PubMed
PMID: 21535324. Epub 2011/05/04. eng.
8. Solimeno LP, Escobar MA, Krassova S, Seremetis S.
Major and Minor Classifications for Surgery in People
With Hemophilia: A Literature Review. Clinical and
applied thrombosis/hemostasis : official journal of
the International Academy of Clinical and Applied
Thrombosis/Hemostasis. 2018;24(4):549-59. PubMed
PMID: 28681633. Epub 2017/07/07. eng.
9. Jerome Wiedel SS, Sue Geraghty, and Sharon Funk.
Joint replacement surgery in hemophilia. World
Federation of Hemophilia. 2010:1-10.
10. Batorova A, Martinowitz U. Intermittent injections
vs. continuous infusion of factor VIII in haemophilia
patients undergoing major surgery. British journal of
haematology. 2000;110(3):715-20. PubMed PMID:
10997985. Epub 2000/09/21. eng.
11. Bjorkman S, Berntorp E. Pharmacokinetics of
coagulation factors: clinical relevance for patients
with haemophilia. Clinical pharmacokinetics. 2001;
40(11):815-32. PubMed PMID: 11735604. Epub
2001/12/12. eng.
12. Treatment of bleeding and perioperative management
in hemophilia A and B [Internet]., 2017. Available from:
https://www.uptodate.com/contents/treatmentof-
bleeding-and-perioperative-management-inhemophilia-
a-and-b.
13. Lusher JM. Use of prothrombin complex concentrates
in management of bleeding in hemophiliacs with
inhibitors--benefits and limitations. Seminars in
hematology. 1994;31(2 Suppl 4):49-52. PubMed
PMID: 7939776. Epub 1994/04/01. eng.
14. Mortazavi SM, Najafi A, Toogeh G. Total joint
replacement in haemophilia A patients with high titre
of inhibitor using a new brand recombinant factor
VIIa (Aryoseven((R)) ). Haemophilia : the official
journal of the World Federation of Hemophilia.
2016;22(5):e451-3. PubMed PMID: 27353311. Epub
2016/06/30. eng.
15. Atilla B, Caglar O, Pekmezci M, Buyukasik Y,
Tokgozoglu A, Alpaslan M. Pre‐operative flexion
contracture determines the functional outcome of
haemophilic arthropathy treated with total knee
arthroplasty. Haemophilia : the official journal of the
World Federation of Hemophilia. 2012;18(3):358-63.
16. DE PALMA AF, Cotler J. Hemophilic arthropathy. AMA
Archives of Surgery. 1956;72(2):247-50.
17. Goddard N, Rodriguez‐Merchan E, Wiedel J. Total
knee replacement in haemophilia. Haemophilia : the
official journal of the World Federation of Hemophilia.
2002;8(3):382-6.
18. Moore M, Tobase P, Allen D. Meta‐analysis: outcomes of
total knee arthroplasty in the haemophilia population.
Haemophilia : the official journal of the World
Federation of Hemophilia. 2016;22(4):e275-e85.
19. Rodriguez‐Merchan E. Correction of fixed contractures
during total knee arthroplasty in haemophiliacs.
Haemophilia : the official journal of the World
Federation of Hemophilia. 1999;5:33-8.
20. Solimeno LP, Pasta G. Knee and ankle arthroplasty
in hemophilia. Journal of clinical medicine. 2017;
6(11):107.
21. Strauss A, Schmolders J, Friedrich M, Pflugmacher
R, Müller M, Goldmann G, et al. Outcome after total
knee arthroplasty in haemophilic patients with stiff
knees. Haemophilia : the official journal of the World
Federation of Hemophilia. 2015;21(4):e300-e5.
22. Innocenti M, Civinini R, Carulli C, Villano M,
Linari S, Morfini M. A modular total knee
arthroplasty in haemophilic arthropathy. The Knee.
2007;14(4):264-8.
23. Song S, Bae J, Park C, Yoo M, Bae D, Kim K. Midterm
outcomes and complications of total knee
arthroplasty in haemophilic arthropathy: A review of
consecutive 131 knees between 2006 and 2015 in a
single institute. Haemophilia : the official journal of
the World Federation of Hemophilia. 2018;24(2):299-
306.
24. Figgie MP, Goldberg VM, Figgie HE, Heiple KG, Sobel M.
Total knee arthroplasty for the treatment of chronic
hemophilic arthropathy. Clin Orthop Relat Res. 1989;
(248):98-107. PubMed PMID: 2805504. eng.
25. Unger AS, Kessler CM, Lewis RJ. Total knee
arthroplasty in human immunodeficiency virusinfected
hemophiliacs. The Journal of arthroplasty.
1995;10(4):448-52. PubMed PMID: 8523002. Epub
1995/08/01. eng.
26. Sheth DS, Oldfield D, Ambrose C, Clyburn T. Total knee
arthroplasty in hemophilic arthropathy. The Journal
of arthroplasty. 2004;19(1):56-60.
27. Rodriguez-Merchan EC. Special features of total
knee replacement in hemophilia. Expert review of
hematology. 2013;6(6):637-42.
28. Rodriguez-Merchan E. Effects of hemophilia
on articulations of children and adults. Clinical
Orthopaedics and Related Research (1976-2007).
1996;328:7-13.
29. Arnold WD, Hilgartner M. Hemophilic arthropathy.
Current concepts of pathogenesis and management.
JBJS. 1977;59(3):287-305.
30. Mortazavi S, Haghpanah B. Anthropometric study
of the hemophilic knee joints undergoing total
knee arthroplasty. WFH 15TH INTERNATIONAL
MUSCULOSKELETAL CONGRESS; Seoul, Republic of
Korea2017. p. 14.
31. Moore MF, Tobase P, Allen DD. Meta-analysis:
outcomes of total knee arthroplasty in the haemophilia
population. Haemophilia : the official journal of the
World Federation of Hemophilia. 2016;22(4):e275-
85. PubMed PMID: 27444973. Epub 2016/07/23.
eng.
32. Mortazavi SMJ, Firoozabadi MA, Najafi A, Mansouri P.
Evaluation of outcomes of suction drainage in patients
with haemophilic arthropathy undergoing total knee
arthroplasty. Haemophilia : the official journal of the
World Federation of Hemophilia. 2017;23(4):e310-e5.
PubMed PMID: 28544490. Epub 2017/05/26. eng.
33. Frauchigera LH, Harstalla R, Kajahna J, Andersonb
S, Egglia S. Bilateral total knee arthroplasty in a
patient with haemophilia A, high inhibitor titre and
aneurysma spurium of the popliteal artery. Swiss Med
Wkly. 2010;140:w13094.
34. Heeg M, Meyer K, Smid W, Horn JV, Meer JVD. Total
knee and hip arthroplasty in haemophilic patients.
Haemophilia : the official journal of the World
Federation of Hemophilia. 1998;4(5):747-51.
35. Kubes R, Salaj P, Hromadka R, Vcelak J, Kubena AA,
Frydrychova M, et al. Range of motion after total
knee arthroplasty in hemophilic arthropathy. BMC
musculoskeletal disorders. 2018;19(1):162. PubMed
PMID: 29788949. Pubmed Central PMCID: 5964921.
36. Legroux-Gérot I, Strouk G, Parquet A, Goodemand
J, Gougeon F, Duquesnoy B. Total knee arthroplasty
in hemophilic arthropathy. Joint Bone Spine. 2003;
70(1):22-32.
37. Mortazavi S, Haghpanah B, Ebrahiminasab M, Baghdadi
T, Hantooshzadeh R, Toogeh G. Simultaneous bilateral
total knee arthroplasty in patients with haemophilia:
a safe and cost‐effective procedure? Haemophilia : the
official journal of the World Federation of Hemophilia.
2016;22(2):303-7.
38. Laskin RS. Ten steps to an easier revision total
knee arthroplasty. The Journal of arthroplasty.
2002;17(4):78-82.
39. Feng B, Weng X-s, Lin J, Qian W-w, Wei W, Zhai J-l,
et al. Outcome of total knee arthroplasty combined
patelloplasty for end-stage type A hemophilic
arthropathy. The Knee. 2012;19(2):107-11.
40. Mortazavi SJ, Haghpanah B, Ebrahiminasab SM.
clinical course of residual flexion contracture after
total knee arthroplasty in patients with hemophilic
arthropathy. Haemophilia : the official journal of the
World Federation of Hemophilia. 2016;22:86.
41. Rodriguez-Merchan EC. The role of orthopaedic
surgery in haemophilia: current rationale, indications
and results. EFORT open reviews. 2019;4(5):165-73.
PubMed PMID: 31191984. Pubmed Central PMCID:
PMC6540948. Epub 2019/06/14. eng.
42. Lobet S, Pendeville E, Dalzell R, Defalque A, Lambert
C, Pothen D, et al. The role of physiotherapy after
total knee arthroplasty in patients with haemophilia.
Haemophilia : the official journal of the World
Federation of Hemophilia. 2008;14(5):989-98.
PubMed PMID: 18582230. Epub 2008/06/28. eng.
43. Rodriguez-Merchan EC. Total knee replacement in
haemophilic arthropathy. The Journal of bone and
joint surgery British volume. 2007;89(2):186-8.
PubMed PMID: 17322432. Epub 2007/02/27. eng.
44. De Kleijn P, Fischer K, Vogely H, Hendriks C, Lindeman
E. In-hospital rehabilitation after multiple joint
procedures of the lower extremities in haemophilia
patients: clinical guidelines for physical therapists.
Haemophilia : the official journal of the World
Federation of Hemophilia. 2011;17(6):971-8. PubMed
PMID: 21457409. Epub 2011/04/05. eng.
45. Forsyth A, Zourikian N. How we treat: Considerations
for physiotherapy in the patient with haemophilia
and inhibitors undergoing elective orthopaedic
surgery. Haemophilia : the official journal of the
World Federation of Hemophilia. 2012;18(4):550-3.
PubMed PMID: 22934294. Epub 2012/08/31. eng.
46. Schick M, Stucki G, Rodriguez M, Meili E, Huber E,
Michel B, et al. Haemophilic; arthropathy: assessment
of quality of life after total knee arthroplasty. Clinical
rheumatology. 1999;18(6):468-72.
47. Goddard NJ, Mann HA, Lee CA. Total knee replacement
in patients with end-stage haemophilic arthropathy:
25-year results. The Journal of bone and joint surgery
British volume. 2010;92(8):1085-9. PubMed PMID:
20675751. Epub 2010/08/03. eng.
48. Zingg PO, Fucentese SF, Lutz W, Brand B, Mamisch
N, Koch PP. Haemophilic knee arthropathy: longterm
outcome after total knee replacement. Knee
Surgery, Sports Traumatology, Arthroscopy. 2012;
20(12):2465-70.
49. Wang K, Street A, Dowrick A, Liew S. Clinical
outcomes and patient satisfaction following total
joint replacement in haemophilia–23‐year experience
in knees, hips and elbows. Haemophilia : the official
journal of the World Federation of Hemophilia.
2012;18(1):86-93.
50. Cancienne JM, Werner BC, Browne JA. Complications
After TKA in Patients With Hemophilia or Von
Willebrand’s Disease. The Journal of arthroplasty.
2015;30(12):2285-9. PubMed PMID: 26143236.
Epub 2015/07/06. eng.
51. Goldberg VM, Heiple KG, Ratnoff OD, Kurczynski
E, Arvan G. Total knee arthroplasty in classic
hemophilia. The Journal of bone and joint surgery
American volume. 1981;63(5):695-701. PubMed
PMID: 7240292. Epub 1981/06/01. eng.
52. Jamsen E, Varonen M, Huhtala H, Lehto MU, Lumio
J, Konttinen YT, et al. Incidence of prosthetic joint
infections after primary knee arthroplasty. The
Journal of arthroplasty. 2010;25(1):87-92. PubMed
PMID: 19056210. Epub 2008/12/06. eng.
53. Silva M, Luck JV, Jr. Long-term results of primary total
knee replacement in patients with hemophilia. The
Journal of bone and joint surgery American volume.
2005;87(1):85-91. PubMed PMID: 15634817. Epub
2005/01/07. eng.
54. Perez Botero J, Spoon DB, Patnaik MS, Ashrani AA,
Trousdale RT, Pruthi RK. Incidence of symptomatic
venous thromboembolism in patients with hemophilia
undergoing joint replacement surgery: a retrospective
study. Thrombosis research. 2015;135(1):109-13.
PubMed PMID: 25434629. Epub 2014/12/02. eng.
55. Pradhan SM, Key NS, Boggio L, Pruthi R. Venous
thrombosis prophylaxis in haemophilics undergoing
major orthopaedic surgery: a survey of haemophilia
treatment centres. Haemophilia : the official
journal of the World Federation of Hemophilia.
2009;15(6):1337-8. PubMed PMID: 19702632. Epub
2009/08/26. eng.
56. AAOS. AAOS Guideline on Preventing Venous
Thromboembolic Disease in Patients Undergoing
Elective Hip and Knee Arthroplasty. https://www.
aaos.org/research/guidelines/vte/vte_full_guideline.
pdf. 2018.
57. Falck-Ytter Y, Francis CW, Johanson NA, Curley C, Dahl
OE, Schulman S, et al. Prevention of VTE in orthopedic
surgery patients: Antithrombotic Therapy and
Prevention of Thrombosis, 9th ed: American College
of Chest Physicians Evidence-Based Clinical Practice
Guidelines. Chest. 2012;141(2 Suppl):e278S-e325S.
PubMed PMID: 22315265. Pubmed Central PMCID:
PMC3278063. Epub 2012/02/15. eng.
58. Rodriguez-Merchan EC, Wiedel JD. Total knee
arthroplasty in HIV-positive haemophilic patients.
Haemophilia : the official journal of the World
Federation of Hemophilia. 2002;8(3):387-92. PubMed
PMID: 12010439. Epub 2002/05/16. eng.
59. Solimeno LP, Mancuso ME, Pasta G, Santagostino E,
Perfetto S, Mannucci PM. Factors influencing the longterm
outcome of primary total knee replacement
in haemophiliacs: a review of 116 procedures at a
single institution. British journal of haematology.
2009;145(2):227-34. PubMed PMID: 19236610.
Epub 2009/02/25. eng.
60. Zhu W, He X, Xia Z, Zhai J, Weng X. Hemophilic
arthropathy in a patient with multi-joint replacement:
A case report and literature review. Medicine.
2018;97(29).
61. Parvizi J, Rasouli M. Simultaneous-bilateral TKA:
Double trouble–affirms. The Journal of bone and joint
surgery British volume. 2012;94(11_Supple_A):90-2.
62. Lombardi AV, Mallory TH, Fada RA, Hartman JF,
Capps SG, Kefauver CA, et al. Simultaneous bilateral
total knee arthroplasties: who decides? Clinical
Orthopaedics and Related Research (1976-2007).
2001;392:319-29.
63. Yoon H-S, Han C-D, Yang I-H. Comparison of
simultaneous bilateral and staged bilateral total knee
arthroplasty in terms of perioperative complications.
The Journal of arthroplasty. 2010;25(2):179-85.
64. Jenny J-Y, Trojani C, Prudhon J-L, Vielpeau C, Saragaglia
D, Houillon C, et al. Simultaneous bilateral total
knee arthroplasty. A multicenter feasibility study.
Orthopaedics & Traumatology: Surgery & Research.
2013;99(2):191-5.
65. Cohen RG, Forrest CJ, Benjamin JB. Safety and efficacy
of bilateral total knee arthroplasty. The Journal of
arthroplasty. 1997;12(5):497-502.
66. Lin AC-C, Chao E, Yang C-M, Wen H-C, Ma H-L, Lu
T-C. Costs of staged versus simultaneous bilateral
total knee arthroplasty: a population-based study of
the Taiwanese National Health Insurance Database.
Journal of orthopaedic surgery and research.
2014;9(1):59.
67. Memtsoudis SG, Della Valle AG, Besculides MC, Gaber
L, Sculco TP. In-hospital complications and mortality
of unilateral, bilateral, and revision TKA: based on an
estimate of 4,159,661 discharges. Clin Orthop Relat
Res. 2008;466(11):2617-27.
68. Bagsby D, Pierson JL. Functional outcomes of
simultaneous bilateral versus unilateral total knee
arthroplasty. Orthopedics. 2015;38(1):e43-e7.
69. Niki Y, Katsuyama E, Takeda Y, Enomoto H, Toyama
Y, Suda Y. Comparison of postoperative morbidity
between simultaneous bilateral and staged bilateral
total knee arthroplasties: serological perspective and
clinical consequences. The Journal of arthroplasty.
2014;29(3):504-9.
70. Hu J, Liu Y, Lv Z, Li X, Qin X, Fan W. Mortality and
morbidity associated with simultaneous bilateral
or staged bilateral total knee arthroplasty: a metaanalysis.
Archives of orthopaedic and trauma surgery.
2011;131(9):1291-8.
71. Fu D, Li G, Chen K, Zeng H, Zhang X, Cai Z. Comparison
of clinical outcome between simultaneous-bilateral
and staged-bilateral total knee arthroplasty: a
systematic review of retrospective studies. The
Journal of arthroplasty. 2013;28(7):1141-7.
72. Rodriguez-Merchan EC. Simultaneous bilateral total
knee arthroplasty in hemophilia: is it recommended?
Expert review of hematology. 2017;10(10):847-51.
73. Rodriguez-Merchan EC. What´s New in Orthopedic
Surgery for People with Hemophilia. Arch Bone Jt Surg.
2018;6(3):157-60. PubMed PMID: 29911131. eng.