Autogenous Osteochondral Grafting for Treatment of Knee Osteochondritis Dissecans: A Case Series Study

Document Type : RESEARCH PAPER

Authors

1 Orthopedic Department Chair, Akhtar Orthopedic Training and Research Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Orthopaedic Research center, Department of Orthopaedic, Poursina Hospital and School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

3 Department of Orthopedics and Traumatology, Ghent University, Ghent, Belgium

4 Akhtar Orthopedic Training and Research Hospital, Shahid Beheshti University of medical Sciences, Tehran, Iran

Abstract

Background: Although some surgical techniques have been described for the operative treatment of unstable
Osteochondritis dissecans (OCD) of the knee, outcomes are variable and are not satisfying totally. The aim of the
present study is to evaluate the outcomes of autogenous osteochondral grafting for OCD of the knee.
Methods: In a case series study, from June 2014 to July 2015, 16 patients with stage II-IV OCD (International Cartilage
Repair Society (ICRS)) of the femoral condyle were investigated. Surgical intervention considered in cases of stage III
(4 cases) and IV (2 cases) and in stage II (10 cases) ones that were nonresponsive to conservative treatment. At the
initial and final visits, the IKDC, Lysholm score and Tegner activity scale were evaluated.
Results: The mean preoperative IKDC score (53.4) increased significantly following surgery (84.3) (p <0.001).
Based on the IKDC grading system, before the operation, the knee status was graded as nearly normal, abnormal,
and severely abnormal in 4, 10, and 2 patients, respectively. At final post-surgical follow up, 15 normal and 1
abnormal knee were documented (p <0.001). The mean Lysholm score increased from 44.3 per operatively to 86.3
(p <0.001).Tegner activity score improved from 2.8±1 pre operatively to 5.6 ±2 (p <0.001).
Conclusion: Surgical treatment of unstable OCD using autogenous osteochondral graft shows successful outcomes.
In addition to reliable fixation, it can enhance healing and convert an uncontained lesion to contained one appropriate
for autogenous osteochondral grafting with healthy cartilage.
Level of evidence: IV

Keywords


1. Gunton MJ, Carey JL, Shaw CR, Murnaghan ML.
Drilling juvenile osteochondritis dissecans: retroor
transarticular? Clinical Orthopaedics and Related
Research®. 2013; 1; 471(4):1144-51.
2. Sasaki K, Matsumoto T, Matsushita T, Kubo S,
Ishida K, Tei K, Akisue T, Kurosaka M, Kuroda R.
Osteochondral autograft transplantation for juvenile
osteochondritis dissecans of the knee: a series of
twelve cases. International orthopaedics. 2012; 1;
36(11):2243-8.
3. Clanton TO, DeLee JC. Osteochondritis dissecans.
History, pathophysiology and current treatment
concepts. Clinical orthopaedics and related research.
1982; (167):50-64.
4. Aichroth P. Osteochondritis dissecans of the knee: a
clinical survey. The Journal of bone and joint surgery.
British volume. 1971; 53(3):440-7.
5. Magnussen RA, Carey JL, Spindler KP. Does operative
fixation of an osteochondritis dissecans loose body
result in healing and long-term maintenance of knee
function? The American journal of sports medicine.
2009; 37(4):754-9.
6. Cahill BR, Phillips MR, Navarro R. The results
of conservative management of juvenile osteochondritis
dissecans using joint scintigraphy: a
prospective study. The American journal of sports
medicine. 1989; 17(5):601-6.
7. Miniaci A, Tytherleigh-Strong G. Fixation of unstable
osteochondritis dissecans lesions of the knee using
arthroscopic autogenous osteochondral grafting
(mosaicplasty). Arthroscopy: The Journal of
Arthroscopic & Related Surgery. 2007; 23(8):845-51.
8. Kobayashi T, Fujikawa K, Oohashi M. Surgical fixation
of massive osteochondritis dissecans lesion using
cylindrical osteochondral plugs. Arthroscopy: The
Journal of Arthroscopic & Related Surgery. 2004;
20(9):981-6.
9. Lyon R, Liu XC, Kubin M, Schwab J. Does
extracorporeal shock wave therapy enhance healing
of osteochondritis dissecans of the rabbit knee?
A pilot study. Clinical Orthopaedics and Related
Research®. 2013; 471(4):1159-65.
10. Shimada K, Yoshida T, Nakata K, Hamada M, Akita S.
Reconstruction with an osteochondral autograft for
advanced osteochondritis dissecans of the elbow.
Clinical Orthopaedics and Related Research®. 2005;
435:140-7.
11. Wall E, Von DS. Juvenile osteochondritis dissecans.
The Orthopedic clinics of North America. 2003;
34(3):341-53.
12. Anderson AF, Lipscomb AB, Coulam C. Antegrade
curettement, bone grafting and pinning of
osteochondritis dissecans in the skeletally mature
knee. The American journal of sports medicine.
1990; 18(3):254-61.
13. Anderson AF, Richards DB, Pagnani MJ, Hovis WD.
Antegrade drilling for osteochondritis dissecans of
the knee. Arthroscopy: The Journal of Arthroscopic
& Related Surgery. 1997; 13(3):319-24.
14. Bradley J, Dandy DJ. Results of drilling osteochondritis
dissecans before skeletal maturity. The Journal
of bone and joint surgery. British volume. 1989;
71(4):642-4.
15. Robertson W, Kelly BT, Green DW. Osteochondritis
dissecans of the knee in children. Current opinion in
pediatrics. 2003; 15(1):38-44.
16. Nakagawa T, Kurosawa H, Ikeda H, Nozawa M,
Kawakami A. Internal fixation for osteochondritis
dissecans of the knee. Knee Surgery, Sports
Traumatology, Arthroscopy. 2005; 13(4):317-22.
17. Hayan R, Phillipe G, Ludovic S, Claude K, Jean-Michel
C. Juvenile osteochondritis of femoral condyles:
treatment with transchondral drilling. Analysis of
40 cases. Journal of children’s orthopaedics. 2010;
4(1):39-44.
18. Steinhagen J, Bruns J, Deuretzbacher G, Ruether W,
Fuerst M, Niggemeyer O. Treatment of osteochondritis
dissecans of the femoral condyle with autologous
bone grafts and matrix-supported autologous
chondrocytes. International orthopaedics. 2010;
34(6):819-25.
19. DC C. Safran MR. Osteochondritis dissecans of the
knee. J Am Acad Orthop Surg. 2006; 14(2):90-100.
20. Flynn JM, Kocher MS, Ganley TJ. Osteochondritis
dissecans of the knee. Journal of Pediatric
Orthopaedics. 2004; 24(4):434-43.
21. Goyal D, Keyhani S, Goyal A, Lee EH, Hui JH, Vaziri
AS. Evidence-based status of osteochondral cylinder
transfer techniques: a systematic review of level I and
II studies. Arthroscopy: The Journal of Arthroscopic
& Related Surgery. 2014; 30(4):497-505.
22. Berlet GC, Mascia A, Miniaci A. Treatment of unstable
osteochondritis dissecans lesions of the knee using 
autogenous osteochondral grafts (mosaicplasty).
Arthroscopy: The Journal of Arthroscopic & Related
Surgery. 1999; 15(3):312-6.
23. Kocher MS, Czarnecki JJ, Andersen JS, Micheli
LJ. Internal fixation of juvenile osteochondritis
dissecans lesions of the knee. The American journal
of sports medicine. 2007; 35(5):712-8.
24. Tuompo P, Arvela V, Partio EK, Rokkanen P.
Osteochondritis dissecans of the knee fixed with
biodegradable self-reinforced polyglycolide and
polylactide rods in 24 patients. International
orthopaedics. 1998; 21(6):355-60.
25. Victoroff BN, Marcus RE, Deutsch A. Arthroscopic
bone peg fixation in the treatment of osteochondritis
dissecans in the knee. Arthroscopy. 1996; 12(4):506-9.
26. Navarro R, Cohen M, Carneiro Filho M, da Silva RT.
The arthroscopic treatment of osteochondritis
dissecans of the knee with autologous bone sticks.
Arthroscopy: The Journal of Arthroscopic & Related
Surgery. 2002; 18(8):840-4.
27. Webb JE, Lewallen LW, Christophersen C, Krych AJ,
McIntosh AL. Clinical outcome of internal fixation of
unstable juvenile osteochondritis dissecans lesions
of the knee. Orthopedics. 2013; 36(11):e1444-9.
28. Camathias C, Gögüs U, Hirschmann MT, Rutz E,
Brunner R, Haeni D, Vavken P. Implant failure after
biodegradable screw fixation in osteochondritis
dissecans of the knee in skeletally immature patients.
Arthroscopy: The Journal of Arthroscopic & Related
Surgery. 2015; 31(3):410-5.
29. Camathias C, Gögüs U, Hirschmann MT, Rutz E,
Brunner R, Haeni D, Vavken P. Implant failure after
biodegradable screw fixation in osteochondritis
dissecans of the knee in skeletally immature patients.
Arthroscopy: The Journal of Arthroscopic & Related
Surgery. 2015; 31(3):410-5.
30. Friederichs MG, Greis PE, Burks RT. Pitfalls associated
with fixation of osteochondritis dissecans fragments
using bioabsorbable screws. Arthroscopy: The
Journal of Arthroscopic & Related Surgery. 2001;
17(5):542-5.
31. Scioscia TN, Giffin JR, Allen CR, Harner CD. Potential
complication of bioabsorbable screw fixation for
osteochondritis dissecans of the knee. Arthroscopy:
The Journal of Arthroscopic & Related Surgery. 2001;
17(2):1-5.
32. Miura K, Ishibashi Y, Tsuda E, Sato H, Toh S. Results
of arthroscopic fixation of osteochondritis dissecans
lesion of the knee with cylindrical autogenous
osteochondral plugs. The American journal of sports
medicine. 2007; 35(2):216-22.