Angioleiomyoma of the Hand: A Case Series and Review of the Literature

Document Type : RESEARCH PAPER


Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA


Background: Angioleiomyomas are rare tumors arising from vascular tissue that can occasionally present in the hand.
Reports of angioleiomyomas in this location are highly limited. Here, we describe the presentation and outcomes of a
series of cases of angioleiomyomas.
Methods: A retrospective case review of five patients with angioleiomyomas arising in the hand was performed. Patients
were identified via International Classification of Diseases, Ninth and Tenth Revision (ICD-9 and ICD-10) diagnosis
codes and were reviewed through the electronic medical record for demographic information, tumor characteristics,
management, and outcomes. A literature review was also conducted of angioleiomyomas.
Results: Five patients were diagnosed with angioleiomyoma at our institution between 1992 and 2015. Patients
presented with a painful, slow-growing hand mass in all cases. The majority of patients were male and of middle-age.
All of the patients were successfully treated with marginal excision and had full return to functional status without
Conclusion: Angioleiomyomas are rare tumors that can arise in the hand and should be included in the differential
diagnosis of a patient presenting with a painful hand mass. They can be successfully treated with marginal excision.
Level of evidence: IV


1. Vandevender DK, Daley RA. Benign and malignant
vascular tumors of the upper extremity. Hand Clin.
1995; 11(2):161-81.
2. Hachisuga T, Hashimoto H, Enjoji M. Angioleiomyoma.
A clinicopathologic reappraisal of 562 cases. Cancer.
1984; 54(1):126-30.
3. Lawson GM, Salter DM, Hooper G. Angioleiomyomas
of the hand. A report of 14 cases. J Hand Surg Am.
1995; 20(4):479-83.
4. Houdek MT, Rose PS, Shon W, Kakar S. Angioleiomyoma
of the upper extremity. J Hand Surg Am. 2013;
5. Kulkarni MS, Vijayan S, Naik M, Rao SK. A rare tumour
of hand: angioleiomyoma. BMJ Case Rep. 2017;
6. Freedman AM, Meland NB. Angioleiomyomas of
the extremities: report of a case and review of the
Mayo Clinic experience. Plast Reconstr Surg. 1989;
7. Park HJ, Kim SS, Lee SY, Choi YJ, Chung EC, Rho
MH. Sonographic appearances of soft tissue
angioleiomyomas: differences from other
circumscribed soft tissue hypervascular tumors. J
Ultrasound Med. 2012; 31(10):1589-95.
8. Smith J, Wisniewski SJ, Lee RA. Sonographic and
clinical features of angioleiomyoma presenting as a
painful Achilles tendon mass. J Ultrasound Med. 2006;
9. Woo KS, Kim SH, Kim HS, Cho PD. Clinical Experience 
with treatment of angioleiomyoma. Arch Plast Surg.
2014; 41(4):374-8.
10. Callé SC, Eaton RG, Littler JW. Vascular leiomyomas in
the hand. J Hand Surg Am. 1994; 19(2):281-6.
11. Yoo HJ, Choi JA, Chung JH, Oh JH, Lee GK, Choi JY, et
al. Angioleiomyoma in soft tissue of extremities: MRI
findings. Am J Roentgenol. 2009; 192(6):W291-4.
12. Hwang JW, Ahn JM, Kang HS, Suh JS, Kim SM, Seo JW.
Vascular leiomyoma of an extremity: MR imagingpathology
correlation. Am J Roentgenol. 1998;
13. Uchida M, Kojima T, Hirase Y, Lizuka T. Clinical
characteristics of vascular leiomyoma of the upper
extremity: report of 11 cases. Br J Plast Surg. 1992;
14. Kanitakis J. Angioleiomyoma of the auricle: an unusual
tumor on a rare location. Case Rep Otolaryngol. 2017;
15. Morimoto N. Angioleiomyoma [vascular leiomyoma]-a
clinicopathologic study. Med J Kagoshima Univ. 1974;
16. Matsuyama A, Hisaoka M, Hashimoto H. Angioleiomyoma:
a clinicopathologic and immunohistochemical
reappraisal with special reference to the correlation
with myopericytoma. Hum Pathol. 2007; 38(4):645-51.
17. Shafi M, Hattori Y, Doi K. Angioleiomyoma of distal
ulnar artery of the hand. Hand (N Y). 2010; 5(1):82-5.
18. Gombos Z, Zhang PJ. Glomus tumor. Arch Pathol Lab
Med. 2008; 132(9):1448-52.