Creep behavior of Biodegradable Triple-component Nanocomposites Based on PLA/PCL/bioactive Glass for ACL Interference Screws

Document Type : RESEARCH PAPER


1 Orthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran Esfarayen University of Technology, Esfarayen, North Khorasan, Iran

2 Biomaterials Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Tehran, Iran

3 Orthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran

4 Central Laboratory Faculty, Iran Polymers and Petrochemical Institute, Tehran, Iran


Background: Short-time creep behaviorfor aseries of biodegradable nanocomposites, which areused as implantable
devices inthe body, is a crucial factor.The present study aimed to investigate the effect of bioactive glass nanoparticles
(BGn) on creep and creep-recovery behaviors of polylactic acid/polycaprolactone (PLA/PCL) blends at different given
loads and different applied temperatures.
Methods: A series of biodegradable nanocomposites consisted of PLA/PCL blends (comprising 80 parts PLA and 20
parts PCL) with different amounts of modified-BGn (m-BGn) fillers were prepared using the evaporated solvent casting
technique. Creep and creep-recovery behaviors of all specimens were studied at different valuable stressesof 3 and 6
MPa and different given temperatures of 25 and 37°C.
Results: In all cases, m-BGn improved the creep resistance of the nanocomposites due to the retardation effect
during the creep behaviors of the nanocomposite systems. The obtained results in terms of creep and creep-recovery
properties determined that the nanocomposites of PLA/PCL/m-BGn can satisfy the required conditions of an appropriate
anterior cruciate ligament reconstruction (ACL-R) screw.
Conclusion: The obtained results confirmed that the BGn plays an impeding role in the movement of PLA/PCL chains
leading to in increase the creep resistance. According to the results, it was determined that the nanocomposites of PLA/
PCL and m-BGn can satisfy the required circumstances of a proper ACL-R screw.
Level of evidence: I


Main Subjects

1. Girgis FG, Marshall JL, Monajem A. The cruciate
ligaments of the knee joint. Anatomical, functional
and experimental analysis. ClinOrthopRelat Res.
1975; 106(1):216-31.
2. Balazs GC, Pavey GJ, Brelin AM, Pickett A, Keblish DJ,
Rue JP. Risk of anterior cruciate ligament injury in
athletes on synthetic playing surfaces: a systematic
review. Am J Sports Med. 2015; 43(7):1798-804.
3. van Eck CF, Fu FH. Anatomic anterior cruciate ligament
reconstruction using an individualized approach.
AsiaPacific J Sports Med ArthroscRehabilitTechnol.
4. Georgiopoulos P, Kontou E. Τhe effect of wood‐fiber
type on the thermomechanical performance of a
biodegradable polymer matrix. J Appl Polymer Sci.
5. Cyras VP, Martucci JF, Iannace S, Vazquez A.
Influence of the fiber content and the processing
conditions on the flexural creep behavior of sisal-
PCL-starch composites. J Thermop Composite Mater.
6. Kim JS, Muliana AH. A combined viscoelastic–
viscoplastic behavior of particle reinforced composites.
Int J Solids Structures. 2010;47(5):580-94.
7. Esmaeilzadeh J, Hesaraki S, Hadavi SM, Esfandeh M,
Ebrahimzadeh MH. Microstructure and mechanical
properties of biodegradable poly (D/L) lactic
acid/polycaprolactone blends processed from the
solvent-evaporation technique. Mater SciEng C.
8. Esmaeilzadeh J, Hesaraki S, Hadavi SM, Ebrahimzadeh
MH, Esfandeh M. Poly (D/L) lactide/polycaprolactone/
bioactive glasssnanocomposites materials for anterior
cruciate ligament reconstruction screws: The effect
of glass surface functionalization on mechanical
properties and cell behaviors. Mater SciEng C.
9. Hanemann T, Szabó DV. Polymer-nanoparticle
composites: from synthesis to modern applications.
Materials. 2010;3(6):3468-517.
10. Pegoretti A, Kolarik J, Peroni C, Migliaresi C.
Recycled poly (ethylene terephthalate)/layered
silicate nanocomposites: morphology and tensile
mechanical properties. Polymer. 2004;45(8):2751-9.
11. Pérez CJ, Alvarez VA, Vazquez A. Creep behaviour
of layered silicate/starch–polycaprolactone blends
nanocomposites. Mater SciEng A. 2008;480(1-
12. Patricio T, Glória A, Bártolo P. Mechanical and
biological behaviour of PCL and PCL/PLA scaffolds
for tissue engineering applications. Chem Eng.
13. Patrí􀆴cio T, Bártolo P. Thermal stability of PCL/PLA
blends produced by physical blending process. Proc
Eng. 2013;59(1):292-7.
14. Wu D, Wang J, Zhang M, Zhou W. Rheology of
carbon nanotubes–filled poly (vinylidene fluoride)
composites. IndustEngChem Res. 2012;51(19):
15. Wu DF, Sun YR, Wu L, Zhang M. Kinetic study on the
melt compounding of polypropylene/multi-walled
carbon nanotube composites. J PolymSci Part B
Polym Phys. 2009;47(1):608-18.
16. Wu D, Wu L, Zhang M, Zhao Y. Viscoelasticity and
thermal stability of polylactide composites with
various functionalized carbon nanotubes. Polymer
DegradStabil. 2008;93(8):1577-84.
17. Yao Z, Wu D, Chen C, Zhang M. Creep behavior
of polyurethane nanocomposites with carbon
nanotubes. Composites Part AApplSciManufactur.
18. Chłopek J, Kmita G, Rosół P. Lifetime prediction of
polymer composite implants based on creep and
fatigue tests. Ann Transplanta. 2004;9(1):26-9.