Denosumab in Patients with Giant Cell Tumor and Its Recurrence: A Systematic Review



1 Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran

2 Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran


Recent studies suggest that Denosumab reduces tumor size, therefore, makes the surgery easier with lower
morbidity. However, some studies have reported several complications for this drug. So, this systematic review
was performed to determine the effectiveness and safety of Denosumab in reducing bone destructions activity of
giant cell tumor and skeletal-related events (SRE) in affected patients with giant cell tumor of bone (GCTB) and its
We explored studies in PubMed, and Cochrane Library. For this purpose, articles of various levels were retrieved
until October 22, 2016. Two reviewers assessed the articles independently based on predefined criteria to extract the
relevant data. Primary outcomes associated with skeletal-related event, overall survival, and secondary outcomes
such as pain, quality of life and adverse events were evaluated and analyzed.
The total population of this meta-analysis consisted of 686 patients. Of this population, 55% had primary GCTB and
45% had giant cell tumor recurrence, with 2% experiencing secondary recurrence.
The results showed the effectiveness of Denosumab in reducing the tumor size due to inhibiting the Osteoclastogenesis.
Denosumab didnot show any effect on reducing tumor recurrence, but, in cases where complete tumor surgery is
not possible and tumor residuals may remain, Denosumab can be helpful. Also, the clinicians should consider the
risk benefit of Denosumab.


Main Subjects

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