Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
10.22038/abjs.2025.88678.4020
Abstract
The existing literature on whether subchondral bone injections in knee OA is advisable for relieving patient pain is minimal and the level of evidence is low. A recent case series (2023) analyzed 30 individuals with knee OA (Kellgren-Lawrence 2-3). It showed that combined intraarticular and subchondral BMAC (bone marrow aspirate concentrate injections) provided clinical and imaging benefits up to 24 months for the treatment of symptomatic knee OA, with a low failure rate, and a significant reduction of bone marrow edema. Besides, VAS (visual analog scale) pain worsened at the final follow-up, although remained lower compared to the baseline value. Although some studies mention that subchondral bone injections can relieve pain in mild/moderate knee OA, it does not seem reasonable to advise it until better-designed research can confirm the preliminary studies discussed in this article.
RODRIGUEZ-MERCHAN, E. C. (2025). Subchondral Bone Injections for the Treatment of Knee Osteoarthritis. The Archives of Bone and Joint Surgery, (), -. doi: 10.22038/abjs.2025.88678.4020
MLA
RODRIGUEZ-MERCHAN, E. C. . "Subchondral Bone Injections for the Treatment of Knee Osteoarthritis", The Archives of Bone and Joint Surgery, , , 2025, -. doi: 10.22038/abjs.2025.88678.4020
HARVARD
RODRIGUEZ-MERCHAN, E. C. (2025). 'Subchondral Bone Injections for the Treatment of Knee Osteoarthritis', The Archives of Bone and Joint Surgery, (), pp. -. doi: 10.22038/abjs.2025.88678.4020
CHICAGO
E. C. RODRIGUEZ-MERCHAN, "Subchondral Bone Injections for the Treatment of Knee Osteoarthritis," The Archives of Bone and Joint Surgery, (2025): -, doi: 10.22038/abjs.2025.88678.4020
VANCOUVER
RODRIGUEZ-MERCHAN, E. C. Subchondral Bone Injections for the Treatment of Knee Osteoarthritis. The Archives of Bone and Joint Surgery, 2025; (): -. doi: 10.22038/abjs.2025.88678.4020
)