Table 1 summarizes recommendations based on the presented papers. To prevent infection, it is critical to identify high-risk patients and control those risks prior to surgery. Action must be taken at every step of the surgical process, from preoperative to postoperative protocols, including intraoperative measures. In this Editorial some recent issues that surgeons should explore to try to prevent infection after TKA have been reviewed. Our goal must be to lower the current rate of infection following TKA.