Document Type: RESEARCH PAPER
The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA
Background: Allogeneic blood transfusion in patients undergoing total joint arthroplasty (TJA) has been shown to
negatively affect patient outcomes. This study aimed to examine if there is a correlation between operative time and the
need for allogeneic blood transfusions during TJA.
Methods: We performed a retrospective review of 866 patients who underwent primary TJA during a one-year period
at our institution. Logistic regression was performed to identify the association between operative time and need for
allogeneic blood transfusion, controlling for other patient and surgical factors. Multiple linear regression analysis was
also performed to see how the same factors affected CBL.
Results: Of the 866 cases, 13%(115) were simultaneous bilateral. 52%(449) of patients received preoperative
autologous blood donation. The average operative time for unilateral and bilateral patients was 74.1±(33.9) and
132.6±(36.0) minutes, respectively. Average CBL for unilateral patients was 2120mL±(1208) and 4051mL±(1311) for
bilateral cases. The average number of allogeneic transfusions was also higher within the bilateral group (0.49 vs 1.15
units). Multivariate analysis indicated that duration of surgery (odds ratio [OR]:1.35 per 15 minutes) and bilateral TJA
(OR: 2.97) increase the risk of allogeneic blood transfusion, while patients having total knee arthroplasty are less likely
to receive allogeneic blood transfusion (OR: 0.50). CBL also increased significantly with surgical duration (211.5 mL
per 15 minutes).
Conclusion: A subgroup analysis confirmed that there was a correlation between operative time and need for
allogeneic transfusion following unilateral TJA. Expeditious surgery can minimize blood loss and subsequent need for
blood transfusion and its associated adverse consequences.