Gharanizadeh, K., Aminizadeh, S., Molavi, N., Darbandi, A., Nadjafi, S., Fadavi ghaffari, M., Shooshtarizadeh, T. (2018). Effect of Zoledronic Acid and Vitamin E on Surgical–Induced Femoral Head Osteonecrosis in Rabbit. The Archives of Bone and Joint Surgery, (), -. doi: 10.22038/abjs.2017.24074.1629
Kaveh Gharanizadeh; Sina Aminizadeh; Nima Molavi; Amir Darbandi; Shabnam Nadjafi; Mahsa Fadavi ghaffari; Tina Shooshtarizadeh. "Effect of Zoledronic Acid and Vitamin E on Surgical–Induced Femoral Head Osteonecrosis in Rabbit". The Archives of Bone and Joint Surgery, , , 2018, -. doi: 10.22038/abjs.2017.24074.1629
Gharanizadeh, K., Aminizadeh, S., Molavi, N., Darbandi, A., Nadjafi, S., Fadavi ghaffari, M., Shooshtarizadeh, T. (2018). 'Effect of Zoledronic Acid and Vitamin E on Surgical–Induced Femoral Head Osteonecrosis in Rabbit', The Archives of Bone and Joint Surgery, (), pp. -. doi: 10.22038/abjs.2017.24074.1629
Gharanizadeh, K., Aminizadeh, S., Molavi, N., Darbandi, A., Nadjafi, S., Fadavi ghaffari, M., Shooshtarizadeh, T. Effect of Zoledronic Acid and Vitamin E on Surgical–Induced Femoral Head Osteonecrosis in Rabbit. The Archives of Bone and Joint Surgery, 2018; (): -. doi: 10.22038/abjs.2017.24074.1629
Effect of Zoledronic Acid and Vitamin E on Surgical–Induced Femoral Head Osteonecrosis in Rabbit
1Assistant Professor of Hip Surgeon, MD. Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
2Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital,MD. Iran University of Medical Sciences (IUMS), Tehran, Iran
3Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
4Doctor of Veterinary Medicine. Rajaie Cardiovascular,Medical and Research Center,Iran University of Medical Sciences(IUMS), Tehran, Iran
5Assistant Professor of Pharmacology, MD. Iran University of Medical Sciences (IUMS), Tehran, Iran
6Occupational therapist,MSc. Iran University of Medical Sciences (IUMS), Tehran, Iran
7Department of Pathology and Laboratory Medicine, Shafa Yahyaeyan Orthopedic Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
Abstract
Objectives: Femoral head osteonecrosis is a progressive disease with disabling outcomes in hip joint if not treated. This study was designed to compare the effects of zoledronic acid plus vitamin E versus zoledronic acid alone in femoral head osteonecrosis induced by surgical method in rabbits. Methods: 26 Japanese white adult male normal rabbits at 28-32 weeks old were underwent surgical femoral dislocation to devastate the femoral neck vessels; the femoral neck vessels were ligated. Next, the first 10 rabbits received Zoledronic acid alone; the second group (10 rabbits) received the zoledronic acid plus oral vitamin E and the third group was considered as control group. The treatment process was persisted for 12 weeks and the radiographic and postmortem pathological assessments were performed. The Ficat classification, Epiphyseal Quotient, new bone formation, and residual necrotic bone were assessed. The results were analyzed by statistical chi-square, paired t-tests, independent t-test, Fisher’s test and p-value < 0.05 was considered significant. Results: There were significant statistical difference between the combination therapy group with control for Ficat at 12th weeks (p-value=0.048). Also, both treated groups with control had significant statistical difference for RNB (p-value=0.015). There were no statistically significant differences between three groups for Ficat at 6th week, EQ at 6th and 12th week and NBF (p-value ≥ 0.05) in comparing the three groups. Conclusion: Although zoledronic acid therapy along with vitamin E could improve some radiologic and pathological indices related to femoral head osteonecrosis, vitamin E showed relative impact. Keywords: Zoledronic acid, Vitamin E, Femoral head osteonecrosis
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