TY - JOUR ID - 15447 TI - Molecular Aspects of Co-morbidities in COVID-19 Infection JO - The Archives of Bone and Joint Surgery JA - ABJS LA - en SN - 2345-4644 AU - Pouya, Farzaneh AU - Imani Saber, Zeynab AU - Kerachian, Mohammad Amin AD - 1 Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2 Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - 1 Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2 Department of Medical Genetics, Faculty of Medicine Y1 - 2020 PY - 2020 VL - 8 IS - Supplement 1 SP - 226 EP - 230 KW - Cancer KW - Cardiovascular KW - Chronic Obstructive Pulmonary Disease KW - COVID-19 KW - Diabetes Mellitus KW - Hypertension DO - 10.22038/abjs.2020.47828.2361 N2 - Coronaviruses are a group of enveloped viruses with single-stranded non-segmented positive-sense RNA genomes. InDecember 2019, SARS-CoV-2 appeared in China for the first time and quickly spread throughout the world. Althoughcertain medications suggested for other afflictions tend to be potentially effective for curing the infection, there is noapproved vaccination or drug available for this virus yet. Comprehension of the disease molecular pathogenesis couldprovide useful tools for COVID-19 patients in surveillance, prognosis, treatment, vaccine development and therapeutictargeting. The present research aims to summarize the association in COVID-19 patients between molecular dimensionsof comorbidities with clinical and preclinical information.Developing an ACE2 inhibitor could be a possible therapeutic target. Plasmin is another possible candidate both indiagnosis and treatment areas. All predicted biomarkers must be validated either through randomized clinical trials orexperimental assays before clinical application in patients.Level of evidence: V UR - https://abjs.mums.ac.ir/article_15447.html L1 - https://abjs.mums.ac.ir/article_15447_1eafc6039b734da80bf8864d162ee821.pdf ER -