%0 Journal Article %T Autologous and Allogenic Utilization of Stromal Vascular Fraction and Decellularized Extracellular Matrices in Orthopedic Surgery: A Scoping Review %J The Archives of Bone and Joint Surgery %I Mashhad University of Medical Sciences, Iranian Society of Knee Surgery, Arthroscopy and Sports Tramatology,Iranian Orthopaedic Association %Z 2345-4644 %A RODRIGUEZ-MERCHAN, E. Carlos %D 2022 %\ 10/01/2022 %V 10 %N 10 %P 827-832 %! Autologous and Allogenic Utilization of Stromal Vascular Fraction and Decellularized Extracellular Matrices in Orthopedic Surgery: A Scoping Review %K bone regeneration %K cartilage regeneration %K Decellularized extracellular matrices %K Osteoarthritis %K Stromal vascular fraction %K Tendon healing %R 10.22038/abjs.2022.59635.2943 %X Background: This narrative review of the literature aims to analyze the utilization of stromal vascular fraction (SVF)and decellularized extracellular matrices (dECMs) in various pathologies related to orthopedic surgery.Methods: A literature search was carried out in PubMed on February 15, 2022, using “Stroma Vascular Fraction andOrthopedic Surgery” and “Decellularized Extracellular Matrices and Orthopedic Surgery” as keywords. A total of 278articles were found, of which 28 papers were selected because they seemed to be the most appropriate concerningthe title of the article.Results: The reported results have shown that intra-articular injection of SVF seems to be a safe and efficaciousmethod for managing knee osteoarthritis (OA). Platelet-rich plasma (PRP) and SVF are safe and effective managementfor intractable Achilles tendinopathy in humans, although subjects treated with SVF recover earlier. There are promisingresults in utilizing adipose-derived mesenchymal stromal cells in chronic lateral epicondylitis of the elbow in athletes.Ready-to-use ECM/SVF gel seems to be a good therapeutic option promoting the regeneration of the articular cartilagein subjects with injuries of the cartilage. The SVF can safely be used to treat diabetic subjects suffering from chronicfoot ulcers.Conclusion: There are scarce high-quality data for utilizing cell-based approach in soft tissue injuries of the knee inathletes. Experimental studies indicate that SVF could be a new option to osseous regeneration. Other experimentalstudies support the utilization of dECMs as a scaffold for the regeneration of large osseous defects, cell-derived dECMsscaffolds to repair articular cartilage injuries, and utilization of xenogeneic acellular muscles to manage volumetricmuscle loss where there is a lack of donor site.Intra-articular injections of SVF seems to be a safe and efficacious method for managing OA of the knee joint. Plateletrichplasma (PRP) and SVF are safe and efficacious methods for the management of intractable Achilles tendinopathyin humans, although subjects treated with SVF recover earlier.Level of evidence: III %U https://abjs.mums.ac.ir/article_21037_75a478f41be4e95b9778b40583381d22.pdf