Does Tranexamic Acid Reduce Bleeding during Femoral Fracture Operation?



1 Anesthesiology Research Center, Guilan University of Medical Sciences (GUMS), Poursina hospital, Rasht, Iran

2 Guilan University of Medical Sciences (GUMS), Orthopedic Research Center, Poursina hospital, Rasht, Iran

3 Guilan University of Medical Sciences (GUMS) Anesthesiology, Research Center, Poursina hospital, Rasht, Iran

4 Guilan University of Medical Sciences, Rasht, Iran


Proximal Femoral shaft fractures are commonly associated with marked blood loss which can lead to
postoperative acute anemia and some other complications.
Tranexamic acid (TA) is an antifibrinolytic medication that reduces intra-and postoperative blood loss and transfusion
requirements during some elective surgeries (1-3).
The aim of this study is to evaluate the effect of intravenous Tranexamic acid (TA) on intraoperative blood loss and a
subsequent need for transfusion in patients who were undergoing surgery for femoral shaft fractures in trauma setting.
Thirty-eight ASA grade I-II patients undergoing proximal femoral shaft fracture surgery with intra medullary
nailing were included in this double blind randomized controlled clinical trial. They were allocated into two groups. Group
I, the intervention group with eighteen patients received 15 mg/kg (TA) via intravenous infusion before surgical incision.
Patients in the placebo group received an identical volume of normal saline.
Hemoglobin level was measured four hours before and after the surgeries. Postoperative blood loss and hemoglobin
change as well as transfusion rates and volumes were compared between the two groups.
Mean Percentage fall in hemoglobin after surgery were 1.75±0.84 and 2.04±1.9 in the study and placebo groups,
respectively (
). Hemoglobin loss was higher in the placebo group. Transfusion rates was lower in TA group
(5.6%) compared to the placebo group (30%) (
). No significant difference in The Allowable Blood Loss during the
surgery was found between the two groups (
Preoperative treatment with TA reduces postoperative blood loss and the need for blood transfusion during
traumatic femoral fracture operation.


Main Subjects