Document Type: RESEARCH PAPER
Department of Neurosurgery, Guilan University of Medical Sciences, Rasht, Iran
Department of P harmacology, Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran
Department of Physiology, Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran
Department of Neurosurgery, Ghaem Hospital, Mashhad, Iran
Background: Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injury in Wistar Rats.
Methods: Spinal cord lesions were made by compressing the cord at T9 level and making a spinal cord contusion. Routine care of each rat was done daily. The LSS scoring system was used to measure the locomotion of these rats and to compare the recovery rate between male and female rats.
Results: The results suggested that there was no significant difference between the two sex in recovery.
Conclusions: To be female does not seem to be a prognostic factor for recovery after SCI. However, this preliminary study should be repeated in other animals and in larger cohorts.
- Thuret S, Moon LD, Gage FH. Therapeutic interventions after spinal cord injury. Nat Rev Neurosci. 2006; 7(8):628-43.
- Greenwald BD, Seel RT, Cifu DX, Shah AN. Gender-related differences in acute rehabilitation lenghts of stay, charges, and functional outcomes for a matched sample with spinal cord injury: a multicenter investigation. Arch Phys med Rehabil. 2001; 82(9):1181-7.
- McColl MA, Charlifue S, Glass C, Lawson N, Savic G. Aging, gender, and spinal cord injury. Arch Phys Med Rehabil. 2004; 85(3):363-7.
- Krause JS, Broderick L. Outcomes after spinal cord injury: comparisons as a function of gender and race and ethniciry. Arch Phys Med Rehabil. 2004; 85(3):355-62.
- Sipski M, Jackson A, Go’mez-Mari’n O, Estores I, Stein A. Effects of gender on neurologic and functional recovery after spinal cord inury. Arch Phys Med Rehabil. 2004; 85(11):1826-36.
- Scivoletto G, Morganti B, Molinari M. Sex-related differences of rehabilitation outcomes of spinal cord lesion patients. Clin Rehabil. 2004; 18(6):709-13.
- Farooque M, Suo Z, Arnold PM, Wulser MJ, Chou CT, Vancura RW, et al. Gender-related differences in recovery of locomotor function after spinal cord injury in mice. Spinal Cord. 2006; 44(3):182-7.
- Hauben E, Mizrahi T, Agranov E, Schwartz M. Sexual dimorphism in the spontaneous recovery from spinal cord injuryL a gender gap in beneficial autoimmunity? Eur J Neurosci. 2002; 16(9):1731-40.
- Swartz KR, Fee DB, Joy KM, Roberts KN, Sun S, Scheff NN, et al. Gender differences in spinal cord injury are not estrogen dependent. J Neurotrauma. 2007; 24(3):473-80.
- Fisher CG, Noonan VK, Smith DE, Wing PC, Dvorak MF, Kwon BK. Motor recovery, functional status, and health-related quality of life in patients with complete spinal cord injuries. Spine (Phila Pa 1976). 2005; 30(19):2200-7.
- Onifer SM, Rabchevsky AG, Scheff SW. Rat models of traumatic spinal cord injury to assess motor recovery. ILAR J. 2007; 48(4):385-95.
- Rahimi-Movaghar V, Yazdi A, Saadat S. Saturated picric acid prevents autophagia and self-mutilation in laboratory rats. Acta Med Iran. 2008; 46(4):283-6.
- Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 1995; 12(1):1-21.
- Sedy J, Urdzikova L, Jendelova P, Sykova E. Methods for behavioral testing of spinal cord injured rats. Neurosci Biobehav Rev. 2008; 32(3):550-80.
- Smith RR, Bruke DA, Baldini AD, Shum-Siu A, Baltzely R, Bunger M, et al. The Lousville Swim Scale: a novel assessment of hindlimb function following spinal cord injury in adult rats. J Neurotrauma. 2006; 23(11):1654-70.
- Collazos-Castro C, Lopez-Dolado D, Nieto-Sampedro S. Locomotor deficiets and adaptive mechanisms after thoracic spinal cord contusion in the adult rat. J Neurotrauma. 2006; 23(1):1-17.
- Krause JS, Kemp B, Coker J. Depression after spinal cord injury: relation to gender, ethnicity, aging, and socioeconomic indicators. Arch Phys Med Rehabil. 2000; 81(8):1099-109.
- New PW, Epi MC. Influence of age and gender on rehabilitation outcomes in nontraumatic spinal cord injury. J Spinal Cord Med. 2007; 30(3):225-37.
- Furlan JC, Krassioukov AV, Fehlings MG. The effects of gender on clinical and neurological outcomes after acute cervical spinal cord injury. J Neurotrauma. 2005; 22(3):368-81.
- Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD. Gender-linked brain injury in experimental stroke. Stroke. 1998; 29(1):159-65.
- Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci. 1999; 19(15):6385-93.
- Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, et al. Systemic administration of 17beta-estradiol reduces apoptotic cell death and improves functional recovery following traumatic spinal cord injury in rats. J Neurotrauma. 2004; 21(3):293-306.
- Kauser K, Sonnenberg D, Tse J, Rubanyi GM. 17 beta-Estradiol attenuates endotoxin-induced excessive nitric oxide production in ovariectomized rats in vivo. Am J Physiol. 1997; 273(1 Pt 2):H506-9.
- Singer CA, Rogers KL, Dorsa DM. Modulation of Bcl-2 expression: a potential component of estrogen protection in NT2 neurons. Neuroreport. 1998; 9(11):2565-8.
- Schumacher M, Akwa Y, Guennoun R, Robert F, Labombarda F, Desarnaud F, et al. Steroid synthesis and metabolism in the nervous system: trophic and protective effects. J Neurocytol. 2000; 29(5-6):307-26.
- Samantaray S, Matzelle DD, Ray SK, Banik NL. Physiological low dose of estrogen-protected neurons in experimental spinal cord injury. Ann N Y Acad Sci. 2010; 1199(9):86-9.
- Samantaray S, Sribnick EA, Das A, Thakore NP, Matzelle D, Yu SP, et al. Neuroprotective efficacy of estrogen in experimental spinal cord injury in rats. Ann N Y Acad Sci. 2010; 1199(9):90-4.
- Chakrabarti M, Haque A, Banik NL, Nagarkatti P, Nagarkatti M, Ray SK. Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration. Brain Res Bull. 2014; 109(4):22-31.
- Gold SM, Voskuhl RR. Estrogen and testosterone therapies in multiple sclerosis. Prog Brain Res. 2009; 175(7):239-51.
- Bayir H, Marion DW, Puccio AM, Wisniewski SR, Janesko KL, Clark RS, et al. Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients. J Neurotrauma. 2004; 21(1):1-8.
- Roof RL, Duvdevani R, Braswell L, Stein DG. Progestrone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats. Exp Neurol. 1994; 129(1):64-9.
- Roof RL, Duvdevani R, Heyburn JW, Stein DG. Progestrone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective. Exp Neurol. 1996; 138(2):246-51.
- Roof RL, Hall ED. Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progestrone. J Neurotrauma. 2000; 17(5):367-88.
- Roof RL, Duvdevani R, Stein DG. Gender influences outcome of brain injury: progesterone plays a protective role. Brain Res. 1993; 607(1-2):333-6.
- Ebrahimzadeh MH, Shojaee BS, Golhasani-Keshtan F, Moharari F, Kachooei AR, Fattahi AS. Depression, anxiety and quality of life in caregiver spouses of veterans with chronic spinal cord injury. Iran J Psychiatry. 2014; 9(3):133-6.