1Department of Pediatric Hematology-Oncology, Dr Sheikh Pediatric Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Pathology, School of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Radiology, Mashhad University of Medical Sciences, Mashhad, Iran
Osteosarcoma (OS) is the eighth common cancer of childhood and its incidence is 4 cases in one million in children younger than 14. Facial OS incidence is estimated between 8 and 10% of OS cases. The main etiology of OS is unknown, but various predisposing factors are proposed such as radiation, radiotherapy, some benign bone diseases like Paget’s disease or fibrous dysplasia. There is a 5-year survival rate of 68% and it decreases with the increase of age. Positive history of radiotherapy is the main predisposing factor for childhood OS. There is some evidence about the X-ray induced mutation in genomic DNA that leads to osteosarcoma. In the present paper we present a 19-month old girl with a mass located in the inferior margin of the left cheek and orbit. Our case is unique with regard to her young age and sex. Moreover, the tumor was located in an uncommon site and her disease was progressive and resistant.
Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Cancer Treat Res. 2009;152:3-13.
Yu XC, Xu M, Song RX, Xu SF. Marginal resection for osteosarcoma with effective preoperative chemotherapy. Orthop Surg. 2009;1(3):196-202.
Gao S, Zheng Y, Cai Q, Yao W, Wang J. Preliminary clinical research on epiphyseal distraction in osteosarcoma in children. World J Surg Oncol. 2014; 12:251.
Junior AT, de Abreu Alves F, Pinto CA, Carvalho AL, Kowalski LP, Lopes MA. Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. Oral Oncol. 2003; 39(5):521-30.
Masrouha KZ, Musallam KM, Samra AB, Tawil A, Haidar R, Chakhachiro Z, et al. Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing’s sarcoma. Skeletal Radiol. 2012; 41(11):1453-61.
Khandekar S, Dive A, Munde P, Fande PZ. Chondroblastic osteosarcoma of the left zygomatic bone: Rare case report and review of the literature. J Oral Maxillofac Pathol. 2014; 18(2):281-5.
Ottaviani G, Robert RS, Huh WW, Palla S, Jaffe N. Sociooccupational and physical outcomes more than 20 years after the diagnosis of osteosarcoma in children and adolescents: limb salvage versus amputation. Cancer. 2013; 119(20):3727-36.
Lanzkowsky P. Manual of Pediatric Hematology and Oncology, 5th ed. Waltham, Massachusetts: Academic Press; 2010.
Gadwal SR, Gannon FH, Fanburg-Smith JC, Becoskie EM, Thompson LD. Primary osteosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 22 cases with a review of the literature. Cancer. 2001; 91(3):598-605.
Amaral MB, Buchholz I, Freire-Maia B, Reher P, de Souza PE, Marigo Hde A, et al. Advanced osteosarcoma of the maxilla: a case report. Med Oral Patol Oral Cir Bucal. 2008; 13(8):492-5.
Feng T, Qiao G, Feng L, Qi W, Huang Y, Yao Y, et al. Stathmin is key in reversion of doxorubicin resistance by arsenic trioxide in osteosarcoma cells. Mol Med Rep. 2014;10(6):2985-92.
Etzold A, Schroder JC, Bartsch O, Zechner U, Galetzka D. Further evidence for pathogenicity of the TP53 tetramerization domain mutation p.Arg342Pro in Li-Fraumeni syndrome. Fam Cancer. 2015;14(1):161-5.
Mucke T, Mitchell DA, Tannapfel A, Wolff KD, Loeffelbein DJ, Kanatas A. Effect of neoadjuvant treatment in the management of osteosarcomas of the head and neck. J Cancer Res Clin Oncol. 2014; 140(1):127-31.
Daw NC, Mahmoud HH, Meyer WH, Jenkins JJ, Kaste SC, Poquette CA, et al. Bone sarcomas of the head and neck in children: the St Jude Children’s Research Hospital experience. Cancer. 2000;88(9):2172-80.