Granular cell tumor is a rare benign neoplasm most commonly appears in the head and neck region, especially in the tongue, cheek mucosa, and palate. Occurrence in limbs is even rarer. These tumors account for approximately 0.5% of all soft tissue tumors. Granular cell tumor can also affect other organs including skin, breast, and lungs. Local recurrence and metastasis is potentially higher in malignant forms with poor prognosis in respect to the benign counterparts. The average diameter of the tumor is usually about 2-3 cm. We report a granular cell tumor in the leg with an unusual size.
Abrikossoff A. Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virchow Arch Path Anat. 1926; 260: 215–33.
Rose B, Tamvakopoulos GS, Yeung E, Pollock R, Skinner J, Briggs T, et al. Granular cell tumours: A rare entity in the musculoskeletal system. Sarcoma. 2009; 2009:765927.
Becelli R, Perugini M, Gasparini G, Cassoni A, Fabiani F. Abrikossoff’s tumor. J Craniofac Surg. 2001; 12:78-81.
Speight P. Granular cell tumor. In: Barnes L, Eveson JW, Reichart P, Sidransky D, eds. Pathology and Genetics of Head and Neck Tumours. World Health Organization Classification of Tumours. Lyon, France: IARC Press; 2005:185-6.
Rosai J. Soft tissues. In: Rosai and Ackermans Surgical Pathology. 10th ed. Maryland Heights, Missouri: Mosby; 2011:2105-232.
Elkousy H, Harrelson J, Dodd L, Martinez S, Scully S. Granular cell tumors of the extremities. Clin Orthop Relat Res. 2000; 380:191–8.
Enginger FM, Weiss S. Granular cell tumor. In: Soft Tissue Tumors. 4th ed. Maryland Heights, Missouri: Mosby; 2004:1178–87.
Thacker MM, Humble SD, Mounasamy V, Temple HT, Scully SP. Case report. Granular cell tumors of extremities: comparison of benign and malignant variants. Clin Orthop Relat Res. 2007;455:267–73.
Fisher ER, Wechsler H. Granular cell myoblastoma--a misnomer. Electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma). Cancer. 1962; 15:936-54.
Tsuchida T, Okada K, Itoi E, Sato T, Sato K. Intramuscular malignant granular cell tumor. Skeletal Radiol. 1997; 26(2):116-21.