1Orthopedic Research Center, Imam Reza Hospital Mashhad University of Medical Sciences, Mashhad, Iran
2Orthopedic Research Center, Imam Reza Hospital
Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Pathology, Imam Reza Hospital Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Oncology, Imam Reza Hospital Mashhad University of Medical Sciences, Mashhad, Iran
Liposarcoma is a common malignant soft tissue tumor, accounting for 10% to 16% of all sarcomas. Multicentric myxoid liposarcoma is an uncommon condition. Differentiation between several primary tumors and metastasis of a single liposarcoma represents the main difficulty in diagnosis. A 47-years old woman presented with right thigh myxoid liposarcoma and underwent wide margin tumor resection. Other investigations like CXR, abdominal and pelvic CT-scans were negative. After 18 months another myxoid liposarma was found in her ipsi-lateral breast without any evidence of other organs metastasis. Second lesion location, time between two presentation and cytogenetic differences are accepted criteria to site a sarcoma in multicentric category, but in myxoid liposarcoma these can be explained by the special features inherent to this tumor.
Conesa X, Seijas R, Ares O, Huguet P, Perez M. Multicentric liposarcoma. Acta Orthop Belg. 2011; 77: 9-14
Miettinen M. Modern Soft Tissue Pathology: Tumors and Non-Neoplastic Conditions. 1st ed. Cambridge: Cambridge university press; 2010.
Sato H, Minei S, Sugimoto S . Multicentric liposarcoma. Int J Urol. 2004;11:1133-5.
Siegmund H. Lipoblastic sarcomatosis. Virchoows Arch Pathol Anat. 1934;293:458-63.
Knight JC, Renwick PJ, Dal Cin P, Van Den BH, Flether CD. Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. Cancer Res. 1995;55:24-7.
Hanna SA, Qureshi YA, Bayliss L, David LA, O’Donnell P, Judson IR, et al. Late widespread skeletal metastases from myxoid liposarcoma detected by MRI only. World J Surg Oncol. 2008;6:62.
Antonescu CR, Elahi A, Healey JH, Brennan MF, Lui MY, Lewis J, et al. Monocolonality of multifocal myxoid liposarcoma : confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. Clin Cancer Res. 2000;6(7):2788-93.