Document Type: RESEARCH PAPER

Authors

1 1.Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Department of Orthopaedics, Shohadaye Tajrish hospital, Shahid Beheshti Univeristy of Medical Sciences, Tehran, Iran

2 Department of orthopedic surgery, Shohadaye Tajrish Hospital, Shahid beheshti university of medical sciences

3 Department of Orthopedic Surgery, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Department of biostatics, Faculty of paramedical sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Taleghani hospital, research development unit, Department of orthopaedic surgery, ShahidBeheshti University of Medical Sciences, Tehran, Iran

6 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

7 Shiraz University of Medical Sciences, Shiraz, Iran

10.22038/abjs.2020.44095.2206

Abstract

Introduction: The effect of race and ethnicity on some kind of malignant bone tumors including Ewing sarcoma has been proven in different studies. In order to evaluate the latter, national cancer registries may help to increase understanding about potential cancer causes, prevention and control strategies and apply these findings to control health problems among population with similar characteristics.
Method and Materials: A national population-based cancer registry study based on all patients affected by Ewing Sarcoma registered in the Iran National Cancer Registry (INCR) between 2008 and 2015 was designed. Demographic data of microscopically confirmed cases of bone Ewing sarcoma were registered. Patients with Ewing sarcoma were divided in groups to describe the primary site of the tumor (including axial or appendicular bones) and analyzed. In order to analyze the survival rate, randomized selection of the patient through the INCR data-base was made.
Results: Approximately 678 malignant Ewing sarcoma of the bone were identified through the INCR. The mean age of Ewing sarcoma in Iran was 21.53 years. Nearly half of patients were observed at the age group of 15-24. The total crude incidence rate of Ewing sarcoma was 1.29 in 1 million. The mean 5 year survival rate was 47%. The Mean survival rate for study population was 5.53.
Conclusion: The crude incidence rate of Ewing sarcoma in Iran is relatively lower respect to other registries. The majority of patients are in 15-25 years group and shows affection by Ewing sarcoma in an older age. Socioeconomic factors had direct influence on survival rate.

This research has been performed at Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Keywords