1 Mashhad university of medical sciences

2 Orthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran

3 Orthopedic Research Center, Mashhad university of Medical Sciences

4 ATOS Klinik, Heidelberg

5 Orthopedic Research Center, Mashhad University of Medical Sciences


Two stage total hip arthroplasty revision surgery includes foreign material debridment, insertion of antibiotic impregnated cemet spacer, and finally, reimplantation of the prosthesis. This review has aimed to evaluate the efficacy of antibiotic impregnated cemet spacers in infection control and eradication in arthroplasties.
A total of 85 articles on total hip arthroplasty were used in this narrative literature review.
High concentrations of the antibiotic in targeted drug delivery by means of using antibiotic impregnated cemet spacers is effective against infections while reduces the side effects of systemic antibiotic therapy. This results in prevention of bone and muscle atrophy as well as size discrepancy. Also, antibiotic impregnated cement spacers reduce dead space and help stabilize the limb in total hip arthroplasty. Despite all reported drawbacks, antibiotic impregnated cement spacers seem effective in eradicationg infections, although a consensus has not been yet achieved.