Bone and Joint research Center. Shiraz University of Medical Sciences. Shiraz-Iran Orthopedic Department.,Chamran Hospital ,Chamran Blvd. Shiraz-Iran Postal Code: 7194815644


Background: Surgical drainage and antibiotic therapy are the cornerstones of treatment protocols in septic arthritis, but in some circumstances the diagnosis and initiation of treatment may be retarded by slow onset disease course or when the patient’s condition precludes early surgery. Finding ways to decrease the amount of articular injury would be beneficial. This study was designed to evaluate the effects of NSAID on prevention of articular cartilage damage in animal model of staphylococcal septic arthritis
Methods: Knee joints of forty rabbits were infected by intra-articular injection of 105 colony factor unit of Staphylococcus Aureus. Then they were categorized into four groups. The first group (control group) was treated with placebo. The second group was treated with intramuscular injection of Ceftriaxone. The third group was treated with Naproxen only and the fourth group was treated with a combination of Ceftriaxone and Naproxen. All medications were started 24 hours after inoculation of microorganisms in to the knee joint and continued for 3 days. Then the cartilage was evaluated by International Cartilage Repair Society (ICRS) visual histological assessment scale.
Results: Among ICRS visual scale variables, cell viability in tibial side cartilage and surface in both tibial and femoral cartilages were statistically better in cases treated by combination of Ceftriaxone and Naproxen than the group treated by antibiotic alone.
Conclusion: This study would suggest that in case of septic arthritis early administration of NSAID in conjunction with appropriate systemic antibiotic may decrease further articular cartilage damage that is evoked by infection.