1 Department of Chemical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran

2 Targeted Drug Delivery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


Bone disorders are of significant worry due to their increased prevalence in the median age. Scaffold-based bone
tissue engineering holds great promise for the future of osseous defects therapies. Porous composite materials and
functional coatings for metallic implants have been introduced in next generation of orthopedic medicine for tissue
engineering. While osteoconductive materials such as hydroxyapatite and tricalcium phosphate ceramics as well
as some biodegradable polymers are suggested, much interest has recently focused on the use of osteoinductive
materials like demineralized bone matrix or bone derivatives. However, physiochemical modifications in terms of
porosity, mechanical strength, cell adhesion, biocompatibility, cell proliferation, mineralization and osteogenic
differentiation are required. This paper reviews studies on bone tissue engineering from the biomaterial point of view
in scaffolding.


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