TY - JOUR ID - 4701 TI - Giant Cell Tumor of Bone - an Overview JO - The Archives of Bone and Joint Surgery JA - ABJS LA - en SN - 2345-4644 AU - Sobti, Anshul AU - Agrawal, Pranshu AU - Agarwala, Sanjay AU - Agarwal, Manish AD - Department of Orthopaedics, P.D Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai, India AD - Head of Surgey & Orthopaedics, Consultant in Orthopaedics Trauma & Arthroplasty, P.D Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg Mahim, Mumbai, India AD - Consultant in Orthopaedic Oncology & Soft Tissue Tumors, Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg Mahim, Mumbai, India Y1 - 2016 PY - 2016 VL - 4 IS - 1 SP - 2 EP - 9 KW - GCT KW - GCTB KW - Giant cell tumor of bone KW - Review of giant cell tumor DO - 10.22038/abjs.2016.4701 N2 -   Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal cells and the presence of many multi- nucleated giant cells with homogenous distribution. There is no widely held consensus regarding the ideal treatment method selection. There are advocates of varying surgical techniques ranging from intra-lesional curettage to wide resection. As most giant cell tumors are benign and are located near a joint in young adults, several authors favor an intralesional approach that preserves anatomy of bone in lieu of resection. Although GCT is classified as a benign lesion, few patients develop progressive lung metastases with poor outcomes. Treatment is mainly surgical. Options of chemotherapy and radiotherapy are reserved for selected cases. Recent advances in the understanding of pathogenesis are essential to develop new treatments for this locally destructive primary bone tumor. UR - https://abjs.mums.ac.ir/article_4701.html L1 - https://abjs.mums.ac.ir/article_4701_31e16a078c7ae219b67f454aee3c9d54.pdf ER -