TY - JOUR ID - 4294 TI - Avascular Necrosis of the Femoral Head: Are Any Genes Involved? JO - The Archives of Bone and Joint Surgery JA - ABJS LA - en SN - 2345-4644 AU - Pouya, Farzaneh AU - Kerachian, Mohammad Amin AD - Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Genetics, Faculty of Medicine Y1 - 2015 PY - 2015 VL - 3 IS - 3 SP - 149 EP - 155 KW - Avascular KW - Avascular necrosis KW - Femur KW - Osteonecrosis DO - 10.22038/abjs.2015.4294 N2 - Avascular necrosis of the femoral head (ANFH) is a pathologic process that results from interruption of blood supply to the femur bone resulting in the death of bone cells and collapse of the femoral head. Nontraumatic ANFH continuesto be a significant challenge to orthopedic surgeons. While the exact mechanisms remain elusive, many new insights have emerged from research in the last decade that has given us a clearer picture of the pathogenesis of nontraumatic ANFH. Progression to the end stage of ANFH appears to be related to five main mechanisms: hypercoagulable conditions, angiogenesis suppressions, hyperadipogenesis, heritable states, and switching the bone remodelling into bone resorption. Researchers have been examining the pathogenic mechanisms of ANFH but none of these theories have been firmly confirmed although some appear more plausible than the others. All of these factors can switch bone remodelling into bone resorption, which can further lead to ANFH progression ending up to femoral head collapse. UR - https://abjs.mums.ac.ir/article_4294.html L1 - https://abjs.mums.ac.ir/article_4294_ba635771b45c28f0f6acd956e876863a.pdf ER -