Medical Genetics
1. Plasminogen Activator Inhibitor-1 4G/5G Polymorphism Contributes to Osteonecrosis of the Femoral Head Susceptibility: Evidence from a Systematic Review and Meta-analysis

Mohammad R. Sobhan; Masoud Mahdinezhad-Yazdi; Mansour Moghimi; Kazem Aghili; Mohammadali Jafari; Masoud Zare-Shehneh; Hossein Neamatzadeh

Volume 6, Issue 6 , November 2018, , Pages 468-477

Abstract
  Background: The Plasminogen Activator Inhibitor-1 gene 4G/5G (PAI-1 4G/5G) polymorphism has been suggestedto be associated with osteonecrosis of the femoral head (ONFH) susceptibility; however, the results are conflicting andinconclusive. We have carried out a comprehensive meta-analysis to derive a ...  Read More

Hand
2. Comparison of Custom-made Versus Prefabricated Thumb Splinting for Carpometacarpal Arthrosis: A Systematic Review and Meta-analysis

Aslan Baradaran; Ashkan Baradaran; Mohammad H. Ebrahimzadeh; Amir R. Kachooei; Michael Rivlin; Pedro Beredjiklian

Volume 6, Issue 6 , November 2018, , Pages 478-485

Abstract
  Background: The goal of this study was to compare the two types of orthoses, prefabricated soft splints versus shortthermoplastic custom-made splints, that are the most commonly used for the management of first carpometacarpal(CMC) osteoarthritis (OA).Methods: We conducted a meta-analysis and systematic ...  Read More

Tumor
3. Denosumab in Patients with Giant Cell Tumor and Its Recurrence: A Systematic Review

Khodamorad Jamshidi; Mohamad Gharehdaghi; Sami Sam Hajialiloo; Masoud Mirkazemi; Kamran Ghaffarzadehgan; Azra Izanloo

Volume 6, Issue 4 , July 2018, , Pages 260-268

Abstract
  Recent studies suggest that Denosumab reduces tumor size, therefore, makes the surgery easier with lowermorbidity. However, some studies have reported several complications for this drug. So, this systematic reviewwas performed to determine the effectiveness and safety of Denosumab in reducing bone destructions ...  Read More